Orbitofrontal cortex populations are differentially recruited to support actions

被引:9
作者
Cazares, Christian [1 ]
Schreiner, Drew C. [2 ]
Valencia, Mariela Lopez [2 ]
Gremel, Christina M. [1 ,2 ]
机构
[1] Univ Calif San Diego, Neurosci Grad Program, 9500 Gilman Dr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Psychol, 9500 Gilman Dr, La Jolla, CA 92093 USA
关键词
OBSESSIVE-COMPULSIVE DISORDER; ORBITAL PREFRONTAL CORTEX; FRONTAL-CORTEX; DECISION-MAKING; COGNITIVE MAPS; LESIONS; AMYGDALA; REVERSAL; NEURONS; BEHAVIOR;
D O I
10.1016/j.cub.2022.09.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press dura-tions to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the en-coding of ongoing press durations but did not disrupt the use of prior action information to guide future action performance. In contrast, a chronic functional loss of lOFC circuit activity resulted in increased reliance on recently executed lever-press durations and impaired contingency reversal, suggesting the recruitment of compensatory mechanisms that resulted in repetitive action control. Our results identify a novel role for lOFC in the of action information to adaptive behavior.
引用
收藏
页码:4675 / +
页数:19
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