Bioactive Supramolecular Peptide Nanofi bers for Regenerative Medicine

被引：95

作者：

Arslan, Elif ^{[1
]}

Garip, I. Ceren ^{[1
]}

Gulseren, Gulcihan ^{[1
]}

Tekinay, Ayse B. ^{[1
]}

Guler, Mustafa O. ^{[1
]}

机构：

[1] Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey

来源：

ADVANCED HEALTHCARE MATERIALS | 2014年 / 3卷 / 09期

关键词：

self-assembly; peptide amphiphile; regenerative medicine; bioactivity; scaffolds; COLLAGEN-MIMETIC PEPTIDE; MARROW STROMAL CELLS; SELF-ASSEMBLING NANOFIBERS; MESENCHYMAL STEM-CELLS; SER-ARG-ASN; EXTRACELLULAR-MATRIX; BIOMATERIAL SCAFFOLDS; OSTEOBLAST ADHESION; CONTROLLED DELIVERY; CONTROLLED-RELEASE;

D O I：

10.1002/adhm.201300491

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Recent advances in understanding of cell-matrix interactions and the role of the extracellular matrix (ECM) in regulation of cellular behavior have created new perspectives for regenerative medicine. Supramolecular peptide nanofiber systems have been used as synthetic scaffolds in regenerative medicine applications due to their tailorable properties and ability to mimic ECM proteins. Through designed bioactive epitopes, peptide nanofiber systems provide biomolecular recognition sites that can trigger specific interactions with cell surface receptors. The present Review covers structural and biochemical properties of the self-assembled peptide nanofibers for tissue regeneration, and highlights studies that investigate the ability of ECM mimetic peptides to alter cellular behavior including cell adhesion, proliferation, and/or differentiation.

引用

页码：1357 / 1376

页数：20

共 149 条

[1] pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases [J].