Pharmacokinetics of lincomycin following intravenous administration in febrile goats

Disposition of antimicrobials is known to be altered during disease conditions and fever is one of the common manifestations of bacterial infections in animals. The disposition of lincomycin (10 mg/kg, IV) during Echerichia coli endotoxin-induced fever in goats followed two compartment open model and drug was detected in plasma up to 8 h. The high AUC (39.5 +/- 6.21 mu g.h/mL) indicated good antibacterial activity of lincomycin in goats. The volume of distribution and total body clearance were 3.35 +/- 0.45 L/kg and 0.28 +/- 0.03 L/h/kg, respectively. The long elimination half life 9.93 +/- 2.83 h indicated persistence of drug for longer period in body. Lincomycin, is suggested to be repeated at 24 h interval for organisms sensitive to lincomycin having MIC up to 0.6 mu g/mL for the treatment of bacterial infections manifested with fever in goats.