Cancer-targeted functional gold nanoparticles for apoptosis induction and real-time imaging based on FRET

被引：35

作者：

Chen, Wei-Hai

Luo, Guo-Feng

Xu, Xiao-Ding

Jia, Hui-Zhen

Lei, Qi

Han, Kai

Zhang, Xian-Zheng ^{[1
]}

机构：

[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China

来源：

NANOSCALE | 2014年 / 6卷 / 16期

基金：

中国国家自然科学基金;

关键词：

PROAPOPTOTIC PEPTIDE; CELL-DEATH; MITOCHONDRIA; FLUORESCENCE; PROBE; MOLECULES; THERAPY; PROTEIN;

D O I：

10.1039/c4nr02516d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile gold nanoparticle-based multifunctional RB-DEVD-AuNP-DTP has been developed to induce the targeted apoptosis of cancer cells and image in real time the progress of the apoptosis. The multifunctional nanoparticles were demonstrated to have the ability to initiate mitochondria-dependent apoptosis and activate caspase-3 for real-time imaging of the progression of apoptosis.

引用

收藏

页码：9531 / 9535

页数：5

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