Protective Effect of Ginsenoside Rb1 Mixing with Several Lung Flush Solutions on Pulmonary Ischemia-Reperfusion Injury

被引：0
作者：
Lin, Fengwu [2 ]
Zhang, Chuan [3 ]
Zhang, Qiang [2 ]
Cheng, Kunpeng [2 ]
Gao, Nan [2 ]
Han, Zhenguo [2 ]
Zhao, Yan [1 ]
机构：
[1] Jilin Univ, Hosp 2, Dept Endocrine, Changchun 130041, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Thorac Surg, Changchun 130033, Peoples R China
[3] Jilin Univ, Hosp 2, Dept Pediat Surg, Changchun 130021, Peoples R China
来源：
BIOTECHNOLOGY, CHEMICAL AND MATERIALS ENGINEERING III, PTS 1 AND 2 | 2014年 / 884-885卷
关键词：
ginsenoside Rb1; ischemia-reperfusion injury; pulmonary protection; INTERNATIONAL-SOCIETY; PRESERVATION SOLUTION; TRANSPLANTATION; REGISTRY; HEART;
D O I：
10.4028/www.scientific.net/AMR.884-885.625
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Objective: To evaluate the protective effects of ginsenoside Rb1 mixed with LPD compared to mixed with several other lung flush solutions on ischemia-reperfusion injury. Method: Three group of rabbit lungs were perfused with three kinds of mixtures of ginsenoside Rb1 with blood, Euro-Collins solution(EC) or low-potassium-dextran solution(LPD) respectively, then lung dry/wet weight ratio and malondiadehyde(MAD) were examined and histological changes were observed. Result: Lung dry/wet weight ratio of LPD and Rb1 group was higher than that of EC and Rb1 and blood and Rb1 groups, whereas MAD of LPD and Rb1 group was significantly less than that of EC and Rb1 and blood and Rb1 groups (P<0.05). Histological findings showed less damage in LPD and Rb1 group. Conclusion: Ginsenoside Rb1 mixed with LPD shows a better protective effect on pulmonary ischemia-reperfusion injury compared with other mixtures.
引用
收藏
页码：625 / +
页数：3
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