Acoustic behavior of microbubbles and implications for drug delivery

被引：315

作者：

Kooiman, Klazina ^{[1
,2
]}

Vos, Hendrik J. ^{[1
,3
]}

Versluis, Michel ^{[4
]}

de Jong, Nico ^{[1
,2
,3
]}

机构：

[1] Erasmus MC, Dept Biomed Engn, Rotterdam, Netherlands

[2] ICIN, Utrecht, Netherlands

[3] Delft Univ Technol, Fac Sci Appl, Lab Acoust Wavefield Imaging, Delft, Netherlands

[4] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Phys Fluids Grp, NL-7500 AE Enschede, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2014年 / 72卷

关键词：

Ultrasound contrast agent; Acoustic cavitation; Acoustic microstreaming; Microcapsule; Co-administration; Drug uptake; Drug carrier system; Drug release; ULTRASOUND CONTRAST AGENTS; MEDIATED GENE TRANSFECTION; SPEED OPTICAL OBSERVATIONS; GAS-FILLED MICROSPHERES; TARGETED TUMOR-THERAPY; IN-VITRO; FOCUSED ULTRASOUND; SHEAR-STRESS; LOADED MICROBUBBLES; TRIGGERED DRUG;

D O I：

10.1016/j.addr.2014.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they increasingly show potential for drug delivery. This review focuses on the acoustic behavior of flexible-coated microbubbles and rigid-coated microcapsules and their contribution to enhanced drug delivery. Phenomena relevant to drug delivery, such as non-spherical oscillations, shear stress, microstreaming, and jetting will be reviewed from both a theoretical and experimental perspective. Further, the two systems for drug delivery, co-administration and the microbubble as drug carrier system, are reviewed in relation to the microbubble behavior. Finally, future prospects are discussed that need to be addressed for ultrasound contrast agents to move from a pre-clinical tool into a clinical setting. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：28 / 48

页数：21

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