Imaging Intracellular Anticancer Drug Delivery by Self-Assembly Micelles with Aggregation-Induced Emission (AIE Micelles)

被引：151

作者：

Zhang, Chunqiu ^{[1
]}

Jin, Shubin ^{[1
]}

Li, Shengliang ^{[1
]}

Xue, Xiangdong ^{[1
]}

Liu, Juan ^{[1
]}

Huang, Yuran ^{[1
]}

Jiang, Yonggang ^{[1
]}

Chen, Wei-Qiang ^{[2
]}

Zou, Guozhang ^{[1
]}

Liang, Xing-Jie ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2014年 / 6卷 / 07期

基金：

中国国家自然科学基金;

关键词：

tetraphenylethene; self-assembly micelle; aggregation-induced emission; imaging; drug delivery; IN-VIVO; POLYMERIC MICELLES; CANCER-THERAPY; PHOTODYNAMIC THERAPY; NANOPARTICLES; DOXORUBICIN; DENDRIMERS; ENCAPSULATION; VEHICLES; RELEASE;

D O I：

10.1021/am5005267

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanoformulations show many therapeutic advantages over conventional formulations. We seek to develop traceable nanoformulations in order to closely monitor delivery. Herein, we developed a new drug delivery system (DDS) using tetraphenylethene (TPE) to fabricate a self-assembly micelle with aggregation-induced emission (AIE micelle). AIE makes the nanocarriers visible for high-quality imaging, and the switching on and off of the ME is intrinsically controlled by the assembly and disassembly of the micelles. This DDS was tested for doxorubicin (DOX) delivery and intracellular imaging. For the DOX-loaded micelles (TPED), the DOX content reached as much as 15.3% by weight, and the anticancer efficiency was higher than for free DOX. Meanwhile, high-quality imaging was obtained to trace the intracellular delivery of the TPED.

引用

页码：5212 / 5220

页数：9

共 43 条

[1] Polymer-Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery [J].

Aryal, Santosh ;

Hu, Che-Ming Jack ;

Zhang, Liangfang .

ACS NANO, 2010, 4 (01) :251-258

[2] Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery [J].

Chen, Cuie ;

Geng, Jie ;

Pu, Fang ;

Yang, Xinjian ;

Ren, Jinsong ;

Qu, Xiaogang .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (04) :882-886

[3] Fluorescent Polymeric Micelles with Aggregation-Induced Emission Properties for Monitoring the Encapsulation of Doxorubicin [J].

Chen, Jen-Ing ;

Wu, Wen-Chung .

MACROMOLECULAR BIOSCIENCE, 2013, 13 (05) :623-632

[4] Functionalized Single-Walled Carbon Nanotubes as Rationally Designed Vehicles for Tumor-Targeted Drug Delivery [J].

Chen, Jingyi ;

Chen, Shuyi ;

Zhao, Xianrui ;

Kuznetsova, Larisa V. ;

Wong, Stanislaus S. ;

Ojima, Iwao .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (49) :16778-16785

[5] Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery [J].

Chen, Jun ;

Ouyang, Jun ;

Kong, Jiming ;

Zhong, Wen ;

Xing, Malcolm Mq .

ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (08) :3108-3117

[6] Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer [J].

Cheng, Yu ;

Samia, Anna C. ;

Meyers, Joseph D. ;

Panagopoulos, Irene ;

Fei, Baowei ;

Burda, Clemens .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) :10643-10647

[7] Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives [J].

Choi, Ki Young ;

Liu, Gang ;

Lee, Seulki ;

Chen, Xiaoyuan .

NANOSCALE, 2012, 4 (02) :330-342

[8] In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct [J].

Cui, Sisi ;

Yin, Deyan ;

Chen, Yuqi ;

Di, Yingfeng ;

Chen, Haiyan ;

Ma, Yuxiang ;

Achilefu, Samuel ;

Gu, Yueqing .

ACS NANO, 2013, 7 (01) :676-688

[9] Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles [J].

Geng, Y ;

Discher, DE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (37) :12780-12781

[10] Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers [J].

Gillies, ER ;

Jonsson, TB ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (38) :11936-11943

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