机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Huang, Weiwei
[1
,2
]
Zhang, Qishu
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Zhang, Qishu
[1
,2
]
Li, Weiran
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Li, Weiran
[1
,2
]
Chen, Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Chen, Yongjun
[1
,2
]
Shu, Congyan
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Inst Food & Drug Control, Chengdu, Sichuan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Shu, Congyan
[3
]
Li, Qingrong
论文数: 0引用数: 0
h-index: 0
机构:
Kunming Med Univ, Affiliated Hosp 2, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Li, Qingrong
[4
]
Zhou, Jingxian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Zhou, Jingxian
[1
,2
]
Ye, Chao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Ye, Chao
[1
,2
]
Bai, Hongmei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Bai, Hongmei
[1
,2
]
Sun, Wenjia
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Sun, Wenjia
[1
,2
]
Yang, Xu
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Yang, Xu
[1
,2
]
Ma, Yanbing
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Peking Union Med Coll, Kunming, Yunnan, Peoples R ChinaChinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
Ma, Yanbing
[1
,2
]
机构:
[1] Chinese Acad Med Sci, Lab Mol Immunol, Inst Med Biol, Kunming, Yunnan, Peoples R China
[2] Peking Union Med Coll, Kunming, Yunnan, Peoples R China
[3] Sichuan Inst Food & Drug Control, Chengdu, Sichuan, Peoples R China
[4] Kunming Med Univ, Affiliated Hosp 2, Kunming, Yunnan, Peoples R China
Acinetobacter baumannii often causes serious nosocomial infections. Because of its serious drug resistance problems, complex drug resistance mechanism, and rapid adaptation to antibiotics, it often shows pan-drug resistance and high fatality rates, which represent great challenges for clinical treatment. Therefore, identifying new ways to overcome antibiotic resistance is particularly important. In this study, mice immunized with A. baumannii outer membrane vesicles (AbOMVs) produced high IgG levels for a long time, and this antiserum significantly increased the small molecule intracellular aggregation rate and concentrations. In vitro experiments demonstrated that the combined used of anti-AbOMV serum and quinolone antibiotics significantly increased the sensitivity of the bacteria to these antibiotics. Mouse sepsis model experiments demonstrated that delivery of these antibodies using both active and passive immunization strategies significantly improved the susceptibility to quinolone antibiotics, improved the survival rate of mice infected with A. baumannii, and reduced the bacterial load in the organs. In a pneumonia model, the combination of serum anti-AbOMVs and levofloxacin improved levofloxacin sensitivity, which significantly reduced the bacterial loads in the lung and spleen compared with those of the antibiotic or antibody alone. This combination also significantly reduced lung inflammatory cell infiltration and inflammatory cytokine aggregation. In this study, the main protein targets that bound to these antibodies were identified. Structural modeling showed that seven of the proteins were porins. Therefore, we speculated that the anti-AbOMV antibodies mainly improved the intracellular aggregation of antibiotics by affecting porins, thus improving susceptibility to quinolone antibiotics. This study provides a method to improve susceptibility to existing antibiotics and a novel idea for the prevention and treatment of pan-drug-resistant A. baumannii.
机构:
Dalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Shi, Huaying
Zhu, Jie
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Affiliated Hosp 2, Dalian 116021, Liaoning, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Zhu, Jie
Zou, Boyang
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, 9 Lvshun Southern Rd, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Zou, Boyang
Shi, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, 9 Lvshun Southern Rd, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Shi, Lei
Du, Linying
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, 9 Lvshun Southern Rd, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Du, Linying
Long, Yayi
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, 9 Lvshun Southern Rd, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Long, Yayi
Wang, Huaxin
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Wang, Huaxin
Xu, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Xu, Hong
Zhen, Yuhong
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Coll Pharm, 9 Lvshun Southern Rd, Dalian 116044, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
Zhen, Yuhong
Sun, Lidan
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R ChinaDalian Med Univ, Affiliated Dalian Friendship Hosp, 8 Sanba Sq, Dalian 116001, Peoples R China
机构:
Xi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Hlth Sci Ctr, Dept Pathogen Biol & Immunol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
Guo, Yijie
Xun, Meng
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Hlth Sci Ctr, Dept Pathogen Biol & Immunol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
Xun, Meng
Han, Jing
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
机构:
Eastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Guran, Mumtaz
Cakiral, Kadir
论文数: 0引用数: 0
h-index: 0
机构:
Eastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Eastern Mediterranean Univ, Fac Arts & Sci, Dept Chem, Via Mersin 10, TR-99628 Famagusta, North Cyprus, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Cakiral, Kadir
论文数: 引用数:
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机构:
Terali, Kerem
Kandemir, Tulay
论文数: 0引用数: 0
h-index: 0
机构:
Cukurova Univ, Fac Med, Dept Med Microbiol, TR-1380 Adana, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Kandemir, Tulay
论文数: 引用数:
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机构:
Sanliturk, Gizem
Ocal, Melda Meral
论文数: 0引用数: 0
h-index: 0
机构:
Cukurova Univ, Fac Med, Dept Med Microbiol, TR-1380 Adana, Turkiye
Mersin Univ, Fac Sci, Dept Biotechnol, Campus Ciftlikkoy, TR-33343 Yenisehir, Mersin, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Ocal, Melda Meral
Nagiyev, Togrul
论文数: 0引用数: 0
h-index: 0
机构:
Cukurova Univ, Fac Med, Dept Med Microbiol, TR-1380 Adana, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
Nagiyev, Togrul
Koksal, Fatih
论文数: 0引用数: 0
h-index: 0
机构:
Cukurova Univ, Fac Med, Dept Med Microbiol, TR-1380 Adana, TurkiyeEastern Mediterranean Univ, Fac Med, Dept Med Microbiol, Via Mersin 10, TR-99628 Famagusta, North Cyprus, Turkiye
机构:
Ohio State Univ, Med Ctr, Dept Internal Med, Div Infect Dis,Ctr Microbial Interface Biol, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Sopirala, Madhuri M.
Mangino, Julie E.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Internal Med, Div Infect Dis,Ctr Microbial Interface Biol, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Mangino, Julie E.
Gebreyes, Wondwossen A.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Vet Prevent Med, Coll Vet Med, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Gebreyes, Wondwossen A.
Biller, Beth
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Biller, Beth
Bannerman, Tammy
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Dept Hlth, Columbus, OH USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Bannerman, Tammy
Balada-Llasat, Joan-Miquel
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
Balada-Llasat, Joan-Miquel
Pancholi, Preeti
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USAOhio State Univ, Med Ctr, Dept Pathol, Div Clin Microbiol, Columbus, OH 43205 USA
机构:
Yonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South KoreaYonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South Korea
Kim, Yoonjung
Bae, Il Kwon
论文数: 0引用数: 0
h-index: 0
机构:
Silla Univ, Dept Dent Hyg, Busan, South KoreaYonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South Korea
Bae, Il Kwon
Jeong, Seok Hoon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Lab Med, Seoul 135720, South Korea
Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul 135720, South KoreaYonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South Korea
Jeong, Seok Hoon
Yong, Dongeun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Lab Med, Seoul 135720, South Korea
Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul 135720, South KoreaYonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South Korea
机构:
Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R ChinaXi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R China
Guo, Yijie
Wang, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Shaanxi Univ Technol, Dept Biol Sci & Engn, Hanzhong 723001, Peoples R ChinaXi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R China
Wang, Ling
Lei, Jine
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Clin Lab, Xian 710061, Peoples R ChinaXi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R China
Lei, Jine
Xu, Jiru
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R ChinaXi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R China
Xu, Jiru
Han, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R ChinaXi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pathogen Microbiol & Immunol, Xian 710061, Peoples R China
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Chang, Jian-bo
Chen, Yihao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Chen, Yihao
Wang, He
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Lab Med, Beijing, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Wang, He
Ma, Xiaojun
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Infect Dis, Beijing, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Ma, Xiaojun
Zhang, Xiao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Zhang, Xiao
Wu, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Wu, Hao
Ma, Baitao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Ma, Baitao
Zuo, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pharm, Beijing, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Zuo, Wei
Ma, Wenbin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Ma, Wenbin
Wang, Renzhi
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China
Wang, Renzhi
Wei, Junji
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, 1 Shuaifuyuan, Beijing 100730, Peoples R China