Effects of isoflavone supplementation on disturbances in lipid metabolism and antioxidant system due to exogenous cholesterol oxidation products in rats

被引：8
|
作者：
Kaulakami, Yuki [1 ,2 ]
Kiyosawa, Tomoko [1 ,3 ]
Nakamura, Shingo [1 ]
Osada, Kyoichi [1 ,4 ]
机构：
[1] Hirosaki Univ, Fac Agr & Life Sci, Hirosaki, Aomori 0368561, Japan
[2] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutrit Sci, Okayama 7191197, Japan
[3] Aomori Chuo Jr Coll, Dept Food Nutr, Aomori 0300132, Japan
[4] Meiji Univ, Dept Biosci Biotechnol & Agrochem, Tama Ku, Kawasaki, Kanagawa 2148571, Japan
来源：
JOURNAL OF FUNCTIONAL FOODS | 2014年 / 7卷
关键词：
Cholesterol oxidation products; Isoflavone; Lipid metabolism; Oxidative stress; Antioxidant system; DIETARY OXIDIZED CHOLESTEROL; SOY ISOFLAVONES; INHIBITORY-ACTIVITIES; HEPATIC-METABOLISM; SOYBEAN PROTEIN; LIVER; SERUM; 7-KETOCHOLESTEROL; ABSORPTION; OXIDES;
D O I：
10.1016/j.jff.2014.02.009
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Dietary cholesterol oxidation products (COP) cause disturbances in lipid metabolism and antioxidant system. Here we investigated if isoflavone supplementation ameliorated COP-induced disturbances in lipid metabolism and antioxidant system. Male Sprague Dawley rats (4 weeks of age) were fed diets containing 0.2% COP supplemented with or without 0.15% isoflavone aglycones for 3 weeks. Isoflavone supplementation significantly ameliorated the dietary COP-induced decrease in hepatic cholesterol 7 alpha-hydroxylase activity. Isoflavone supplementation also promoted faecal bile acid excretion, restored the decrease in plasma triacylglycerol levels in COP-fed rats, and suppressed COP-induced oxidative stress. Thus, isoflavone supplementation may ameliorate COP-induced deleterious effects by activating hepatic cholesterol 7a-hydroxylase and decreasing COP levels in the body. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：212 / 218
页数：7
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