Effects of isoflavone supplementation on disturbances in lipid metabolism and antioxidant system due to exogenous cholesterol oxidation products in rats

被引：8

作者：

Kaulakami, Yuki ^{[1
,2
]}

Kiyosawa, Tomoko ^{[1
,3
]}

Nakamura, Shingo ^{[1
]}

Osada, Kyoichi ^{[1
,4
]}

机构：

[1] Hirosaki Univ, Fac Agr & Life Sci, Hirosaki, Aomori 0368561, Japan

[2] Okayama Prefectural Univ, Fac Hlth & Welf Sci, Dept Nutrit Sci, Okayama 7191197, Japan

[3] Aomori Chuo Jr Coll, Dept Food Nutr, Aomori 0300132, Japan

[4] Meiji Univ, Dept Biosci Biotechnol & Agrochem, Tama Ku, Kawasaki, Kanagawa 2148571, Japan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2014年 / 7卷

关键词：

Cholesterol oxidation products; Isoflavone; Lipid metabolism; Oxidative stress; Antioxidant system; DIETARY OXIDIZED CHOLESTEROL; SOY ISOFLAVONES; INHIBITORY-ACTIVITIES; HEPATIC-METABOLISM; SOYBEAN PROTEIN; LIVER; SERUM; 7-KETOCHOLESTEROL; ABSORPTION; OXIDES;

D O I：

10.1016/j.jff.2014.02.009

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Dietary cholesterol oxidation products (COP) cause disturbances in lipid metabolism and antioxidant system. Here we investigated if isoflavone supplementation ameliorated COP-induced disturbances in lipid metabolism and antioxidant system. Male Sprague Dawley rats (4 weeks of age) were fed diets containing 0.2% COP supplemented with or without 0.15% isoflavone aglycones for 3 weeks. Isoflavone supplementation significantly ameliorated the dietary COP-induced decrease in hepatic cholesterol 7 alpha-hydroxylase activity. Isoflavone supplementation also promoted faecal bile acid excretion, restored the decrease in plasma triacylglycerol levels in COP-fed rats, and suppressed COP-induced oxidative stress. Thus, isoflavone supplementation may ameliorate COP-induced deleterious effects by activating hepatic cholesterol 7a-hydroxylase and decreasing COP levels in the body. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：212 / 218

页数：7

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