Intestinal permeability of oxytetracycline from chitosan-montmorillonite nanocomposites

被引：34

作者：

Salcedo, Inmaculada ^{[1
]}

Sandri, Giuseppina ^{[2
]}

La Aguzzi, Caro ^{[1
]}

Bonferoni, Cristina ^{[2
]}

Cerezo, Pilar ^{[1
]}

Sanchez-Espejo, Rita ^{[3
]}

Viseras, Cesar ^{[1
,3
]}

机构：

[1] Univ Granada, Sch Pharm, Dept Pharm & Pharmaceut Technol, Granada, Spain

[2] Univ Pavia, Dept Drug Sci, I-27100 Pavia, Italy

[3] Univ Granada, CSIC, Andalusian Inst Earth Sci, Granada 18100, Spain

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 117卷

关键词：

Oxytetracycline; Caco-2; Nanocomposites; Montmorillonite; Chitosan; BIOPOLYMER-CLAY NANOCOMPOSITES; EXCISED RAT JEJUNUM; CACO-2; CELLS; DRUG-DELIVERY; ORAL DELIVERY; NANOPARTICLES; ABSORPTION; DERIVATIVES; PHARMACOKINETICS; SPECTROSCOPY;

D O I：

10.1016/j.colsurfb.2013.11.009

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A nanocomposite based on chitosan and montmorillonite was developed as carrier to improve oral bioavailability of oxytetracycline. The nanocomposite was prepared by simple solid-liquid interaction and loaded with the drug. The loaded nanocomposite was characterized by X-ray powder diffraction, thermal analysis, FTIR spectroscopy and zeta potential. Caco-2 cell cultures were used to evaluate in vitro cytotoxicity and drug permeation. Confocal laser scanning microscopy was also performed to evaluate the eventual entrapment of drug into the Caco-2 cells. Results showed that the nanocomposite was internalized into the cells and effectively enhanced drug permeation, being also biocompatible towards Caco-2 cells. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：441 / 448

页数：8

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