Spherical and Worm-Like Micelles from Fructose-Functionalized Polyether Block Copolymers

被引：7

作者：

Majdanski, Tobias C. ^{[1
,2
]}

Pretzel, David ^{[1
,2
]}

Czaplewska, Justyna A. ^{[1
,2
]}

Vitz, Juergen ^{[1
,2
]}

Sungur, Pelin ^{[1
,2
]}

Hoeppener, Stephanie ^{[1
,2
]}

Schubert, Stephanie ^{[2
,3
]}

Schacher, Felix H. ^{[1
,2
]}

Schubert, Ulrich S. ^{[1
,2
]}

Gottschaldt, Michael ^{[1
,2
]}

机构：

[1] Friedrich Schiller Univ Jena, Lab Organ & Macromol Chem IOMC, Humboldtstr 10, D-07743 Jena, Germany

[2] Friedrich Schiller Univ Jena, JCSM, Philosophenweg 7, D-07743 Jena, Germany

[3] Friedrich Schiller Univ Jena, Inst Pharm, Otto Schott Str 41, D-07743 Jena, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2018年 / 18卷 / 04期

关键词：

bicontinuous structures; encapsulation; filomicelles; fructose; isopropylidene fructose; PEG; TARGETED DRUG-DELIVERY; CELLULAR UPTAKE; POLY(ETHYLENE GLYCOL); CANCER-THERAPY; BREAST-CANCER; POLYMERIC NANOPARTICLES; PEGYLATION; 2D; NANOCARRIERS; FILOMICELLES;

D O I：

10.1002/mabi.201700396

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents the synthesis and characterization of d-fructose modified poly(ethylene glycol) (Fru-PEG) and fructose modified poly(ethylene glycol)-block-poly(ethyl hexyl glycidyl ether) (Fru-PEG-b-PEHG) that are both prepared by initiation with isopropyliden protected fructose, followed by deprotection of the sugar. The block copolymers are self-assembled into micelles, and are subsequently characterized by cryo-TEM and dynamic light scattering. The fluorescent dye Nile red is encapsulated as a model hydrophobic compound and fluorescent marker to perform initial uptake tests with breast cancer cells. The uptake of sugar and nonsugar decorated micelles is compared.

引用

页数：12

共 50 条

[1] Biomimetic filaments: Worm-like micelles of block copolymers.
Discher, DE
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U892 - U892
[2] Targeted worm-like micelles
Discher, DE
Dalhaimer, P
Engler, AJ
Parthasarthy, R
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U4026 - U4027
[3] Core-crosslinked worm-like micelles from polyether-based diblock terpolymers
Elter, Johanna K.
Biehl, Philip
Gottschaldt, Michael
Schacher, Felix H.
POLYMER CHEMISTRY, 2019, 10 (40) : 5425 - 5439
[4] Worm-Like Micelles and Vesicles: Adjusting the Morphology of Self-Assembled Fructose Based Block Copolymers by Fine-Tuning the Processing Parameters
Zhao, Jiacheng
Stenzel, Martina H.
CONTROLLED RADICAL POLYMERIZATION, VOL 2: MATERIALS, 2015, 1188 : 91 - 105
[5] Janus micelles from polyether block copolymers
Wurm, Frederik
Mangold, Christine
Kilbinger, Andreas F. M.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
[6] RELAXATION MECHANISMS IN WORM-LIKE MICELLES
MARQUES, CM
TURNER, MS
CATES, ME
JOURNAL OF NON-CRYSTALLINE SOLIDS, 1994, 172 : 1168 - 1172
[7] Branched worm-like micelles and their networks
Lin, Z
LANGMUIR, 1996, 12 (07) : 1729 - 1737
[8] Rheology and structure of worm-like micelles
Walker, LM
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2001, 6 (5-6) : 451 - 456
[9] Structure and flexibility of worm-like micelles
Jerke, G
Pedersen, JS
Egelhaaf, SU
Schurtenberger, P
PHYSICA B, 1997, 234 : 273 - 275
[10] ABC Triblock Copolymer Micelles: Spherical Versus Worm-Like Micelles Depending on the Preparation Method
Ghasdian, Negar
Buzza, D. Martin A.
Fletcher, Paul D. I.
Georgiou, Theoni K.
MACROMOLECULAR RAPID COMMUNICATIONS, 2015, 36 (06) : 528 - 532

← 1 2 3 4 5 →