Sex steroids and the kidney: role in renal calcium and phosphate handling

被引：36

作者：

Khalil, Rougin ^{[1
]}

Kim, Na Ri ^{[1
]}

Jardi, Ferran ^{[1
]}

Vanderschueren, Dirk ^{[1
]}

Claessens, Frank ^{[2
]}

Decallonne, Brigitte ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Clin & Expt Endocrinol, Herestr 49,Box 902, Leuven, Belgium

[2] Katholieke Univ Leuven, Mol Endocrinol, Herestr 49,Box 901, Leuven, Belgium

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 465卷 / 0C期

关键词：

Calcium; Phosphate; Sex steroids; Testosterone; Estradiol; Kidney; ESTROGEN-RECEPTOR-BETA; HORMONE-REPLACEMENT THERAPY; BONE-MINERAL DENSITY; ANDROGEN RECEPTOR; SERUM PHOSPHORUS; GENDER-DIFFERENCES; PROSTATE-CANCER; PROXIMAL TUBULE; RAT-KIDNEY; NAPI-IIA;

D O I：

10.1016/j.mce.2017.11.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium and phosphate are vital for the organism and constitute essential components of the skeleton. Serum levels are tightly hormonally regulated and maintained by exchange with three major sources: the intestines, the kidney and the bone. The effects of sex steroids on the bone have been extensively studied and it is well known that sex steroid deficiency induces bone loss, indirectly influencing renal calcium and phosphate homeostasis. However, it is unknown whether sex steroids also directly regulate renal calcium and phosphate handling, hereby potentially indirectly impacting on bone. The presence of androgen receptors (AR) and estrogen receptors (ER) in both human and rodent kidney, although their exact localization within the kidney remains debated, supports direct effects. Estrogens stimulate renal calcium reabsorption as well as phosphate excretion, while the effects of androgens are less clear. Many of the studies performed with regard to renal calcium and/or phosphate homeostasis do not correct for the calcium and phosphate fluxes from the bone and intestines, which complicates the differentiation between the direct effects of sex steroids on renal calcium and phosphate handling and the indirect effects via the bone and intestines. The objective of this study is to review the literature and current insight of the role of sex steroids in calcium and phosphate handling in the kidney. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：61 / 72

页数：12

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