Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy

被引：10

作者：

Uchiyama, H

Okamoto, A

Sato, K

Yamada, T

Murakami, S

Yoneda, S

Karta, Y

Tegoshi, T

Arizono, N

机构：

[1] Nantan Gen Hosp, Dept Med, Yagi, Kyoto 6290141, Japan

[2] Kyoto Prefectural Univ Med, Dept Med Zool, Kyoto, Japan

来源：

INTERNAL MEDICINE | 2004年 / 43卷 / 07期

关键词：

falciparum malaria; parasitemia; hemolytic anemia; disseminated intravascular coagulation syndrome; quinine; atovaquone/proguanil combination;

D O I：

10.2169/internalmedicine.43.624

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 22-year-old Japanese man noticed pyrexia and diarrhea after travel to Guinea. Notable physical findings included hepatosplenomegaly. Treatment with oral quinine and minocycline was started after definitive diagnosis of falciparum malaria by blood smear. Initially, parasitemia and body temperature decreased but by the third night of therapy his temperature increased to 40degreesC with a slight increase of parasite count. When quinine treatment was changed to atovaquone/proguanil, his temperature dropped immediately and complete plasmodial elimination was confirmed on microscopic examination. Subsequent recrudescence of the disease was not observed. It was concluded that the antimalarial treatment with atovaquone/proguanil might become invaluable in Japan.

引用

页码：624 / 627

页数：4

共 9 条

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