Solid-State Conformational Flexibility at Work: Zipping and Unzipping within a Cyclic Peptoid Single Crystal

被引：40
作者：
Meli, Alessandra [1 ]
Macedi, Eleonora [1 ]
De Riccardis, Francesco [1 ]
Smith, Vincent J. [2 ]
Barbour, Leonard J. [2 ]
Izzo, Irene [1 ]
Tedesco, Consiglia [1 ]
机构：
[1] Univ Salerno, Dipartimento Chim & Biol A Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy
[2] Univ Stellenbosch, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Stellenbosch, South Africa
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 15期
关键词：
crystal engineering; host-guest systems; noncovalent interactions; peptoids; supramolecular chemistry; HYDROGEN-BONDS; GUEST;
D O I：
10.1002/anie.201511053
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A peptidomimetic compound undergoes a reversible single-crystal-to-single-crystal transformation upon guest release/uptake with the transformation involving a drastic conformational change. The extensive and reversible alteration in the solid state is connected to the formation of an unprecedented CH- zipper which can reversibly open and close (through the formation of CH- interactions), thus allowing for guest sensing.
引用
收藏
页码：4679 / 4682
页数：4
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