Solid-State Conformational Flexibility at Work: Zipping and Unzipping within a Cyclic Peptoid Single Crystal

被引：38

作者：

Meli, Alessandra ^{[1
]}

Macedi, Eleonora ^{[1
]}

De Riccardis, Francesco ^{[1
]}

Smith, Vincent J. ^{[2
]}

Barbour, Leonard J. ^{[2
]}

Izzo, Irene ^{[1
]}

Tedesco, Consiglia ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim & Biol A Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

[2] Univ Stellenbosch, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Stellenbosch, South Africa

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 15期

关键词：

crystal engineering; host-guest systems; noncovalent interactions; peptoids; supramolecular chemistry; HYDROGEN-BONDS; GUEST;

D O I：

10.1002/anie.201511053

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A peptidomimetic compound undergoes a reversible single-crystal-to-single-crystal transformation upon guest release/uptake with the transformation involving a drastic conformational change. The extensive and reversible alteration in the solid state is connected to the formation of an unprecedented CH- zipper which can reversibly open and close (through the formation of CH- interactions), thus allowing for guest sensing.

引用

页码：4679 / 4682

页数：4

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