Breaking down bone: new insight into site-specific mechanisms of breast cancer osteolysis mediated by metalloproteinases

被引：41

作者：

Guise, Theresa A. ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Internal Med, Indianapolis, IN 46202 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 18期

关键词：

EGFR; bone metastasis; breast cancer; metalloprotease; osteoclastogenesis; TRANSFORMING-GROWTH-FACTOR; EGF-LIKE LIGANDS; PROSTATE-CANCER; MATRIX METALLOPROTEINASES; OSTEOCLAST DIFFERENTIATION; SKELETAL COMPLICATIONS; TISSUE INHIBITOR; ZOLEDRONIC ACID; LUNG-CANCER; PHASE-II;

D O I：

10.1101/gad.1854909

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone metastases are the most common skeletal complication of malignancy. Tumor cells disrupt normal bone remodeling to promote bone destruction and its associated morbidity. In the August 15, 2009, issue of Genes & Development, Lu and colleagues (pp. 1882-1894) propose a novel molecular mechanism by which tumor-produced metalloproteinases release epidermal growth factor (EGF) ligands to activate the central osteoclastogenic pathway receptor activator of NF-kappa B ligand (RANKL) to promote breast cancer osteolysis. This work has important therapeutic applications that may quickly translate to more effective treatment for bone metastases.

引用

页码：2117 / 2123

页数：7

共 59 条

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