Hepatic metabolic regulation by nuclear factor E4BP4

被引：18
作者：
Zhao, Zifeng [1 ,2 ]
Yin, Lei [2 ]
Wu, Feihua [1 ]
Tong, Xin [2 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, Nanjing, Jiangsu, Peoples R China
[2] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2021年 / 66卷 / 01期
关键词：
E4BP4; insulin; lipid; glucose; metabolism; TRANSCRIPTION FACTOR E4BP4; PPAR-ALPHA; CIRCADIAN-CLOCK; REPRESSION; CHOLESTEROL; EXPRESSION; GENE; PROTEINS; GLUCOSE; LIVER;
D O I：
10.1530/JME-20-0239
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Discovered as a b-ZIP transcription repressor 30 years ago, E4 promoter-binding protein 4 (E4BP4) has been shown to play critical roles in immunity, circadian rhythms, and cancer progression. Recent research has highlighted E4BP4 as a novel regulator of metabolisms in various tissues. In this review, we focus on the function and mechanisms of hepatic E4BP4 in regulating lipid and glucose homeostasis, bile metabolism, as well as xenobiotic metabolism. Finally, E4BP4-specific targets will be discussed for the prevention and treatment of metabolic disorders.
引用
收藏
页码：R15 / R21
页数：7
相关论文
共 66 条
  • [51] Recruitment of Histone Methyltransferase G9a Mediates Transcriptional Repression of Fgf21 Gene by E4BP4 Protein
    Tong, Xin
    Zhang, Deqiang
    Buelow, Katie
    Guha, Anirvan
    Arthurs, Blake
    Brady, Hugh J. M.
    Yin, Lei
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (08) : 5417 - 5425
  • [52] Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding
    Tong, Xin
    Muchnik, Marina
    Chen, Zheng
    Patel, Manish
    Wu, Nan
    Joshi, Shree
    Rui, Liangyou
    Lazar, Mitchell A.
    Yin, Lei
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (47) : 36401 - 36409
  • [53] The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice
    Tong, Yongbin
    Zeng, Peng
    Zhang, Tianpeng
    Zhao, Mengjing
    Yu, Pei
    Wu, Baojian
    [J]. BIOCHEMICAL PHARMACOLOGY, 2019, 163 : 215 - 224
  • [54] Tornio A, 2018, ADV PHARMACOL, V83, P3, DOI 10.1016/bs.apha.2018.04.007
  • [55] The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
    Urizar, NL
    Dowhan, DH
    Moore, DD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) : 39313 - 39317
  • [56] The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
    Wang, Yuhao
    Kuang, Zheng
    Yu, Xiaofei
    Ruhn, Kelly A.
    Kubo, Masato
    Hooper, Lora V.
    [J]. SCIENCE, 2017, 357 (6354) : 913 - +
  • [57] Transcriptional regulation of hepatic lipogenesis
    Wang, Yuhui
    Viscarra, Jose
    Kim, Sun-Joong
    Sul, Hei Sook
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (11) : 678 - 689
  • [58] Expression profile of mRNAs encoding core circadian regulatory proteins in human subcutaneous adipose tissue: correlation with age and body mass index
    Wu, X.
    Xie, H.
    Yu, G.
    Hebert, T.
    Goh, B. C.
    Smith, S. R.
    Gimble, J. M.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (09) : 971 - 977
  • [59] Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress
    Yang, Meichan
    Zhang, Deqiang
    Zhao, Zifeng
    Sit, Julian
    Saint-Sume, Mischael
    Shabandri, Omar
    Zhang, Kezhong
    Yin, Lei
    Tong, Xin
    [J]. FASEB JOURNAL, 2020, 34 (10) : 13533 - 13547
  • [60] The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases
    Yin, Jinghua
    Zhang, Jian
    Lu, Qianjin
    [J]. CLINICAL IMMUNOLOGY, 2017, 180 : 5 - 10
1234567