Hepatic metabolic regulation by nuclear factor E4BP4

被引：18
作者：
Zhao, Zifeng [1 ,2 ]
Yin, Lei [2 ]
Wu, Feihua [1 ]
Tong, Xin [2 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Pharmacol Chinese Mat Med, Nanjing, Jiangsu, Peoples R China
[2] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2021年 / 66卷 / 01期
关键词：
E4BP4; insulin; lipid; glucose; metabolism; TRANSCRIPTION FACTOR E4BP4; PPAR-ALPHA; CIRCADIAN-CLOCK; REPRESSION; CHOLESTEROL; EXPRESSION; GENE; PROTEINS; GLUCOSE; LIVER;
D O I：
10.1530/JME-20-0239
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Discovered as a b-ZIP transcription repressor 30 years ago, E4 promoter-binding protein 4 (E4BP4) has been shown to play critical roles in immunity, circadian rhythms, and cancer progression. Recent research has highlighted E4BP4 as a novel regulator of metabolisms in various tissues. In this review, we focus on the function and mechanisms of hepatic E4BP4 in regulating lipid and glucose homeostasis, bile metabolism, as well as xenobiotic metabolism. Finally, E4BP4-specific targets will be discussed for the prevention and treatment of metabolic disorders.
引用
收藏
页码：R15 / R21
页数：7
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