The ectodermal control in chick limb development: Wnt-7a, Shh, Bmp-2 and Bmp-4 expression and the effect of FGF-4 on gene expression

被引：16
作者：
Akita, K
FrancisWest, P
Vargesson, N
机构：
[1] TOKYO MED & DENT UNIV, SCH MED, DEPT ANAT, BUNKYO KU, TOKYO 113, JAPAN
[2] UMDS, DEPT CRANIOFACIAL DEV, LONDON SE1, ENGLAND
来源：
MECHANISMS OF DEVELOPMENT | 1996年 / 60卷 / 02期
基金：
英国医学研究理事会;
关键词：
limb development; Wnt-7a; FGF-4; Bmp-2; Bmp-4; Shh; chick; ectoderm;
D O I：
10.1016/S0925-4773(96)00606-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have manipulated the chick limb bud by dorsoventrally inverting the ectoderm, by grafting the AER to the dorsal or ventral ectoderm and by insertion of an FGF-4 soaked heparin bead to the mesoderm. After dorso-ventral reversal of the ectoderm, Wnt-7a expression is autonomous from an early stage of limb development in the original dorsal ectoderm. Exogenous FGF-4 causes ectopic Wnt-7a expression and induces ectopic Shh. In addition, exogenous FGF-4 increases the thickness of cartilages and also shortens them, and both Bmp-2 and Bmp-4 may mediate this effect. The ectoderm outside the AER can regulate not only the dorso-ventral polarity of the underlying mesenchyme cells but also the cartilage formation, and both Bmp-2 and Bmp-4 may mediate this control.
引用
收藏
页码：127 / 137
页数：11
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