In vitro leishmanicidal activity of some scarce natural products

被引：57

作者：

Takahashi, M

Fuchino, H

Sekita, S

Satake, M

机构：

[1] Natl Inst Hlth Sci, Tsukuba Med Plant Res Stn, Tsukuba, Ibaraki 3050843, Japan

[2] Ochanomizu Univ, Inst Environm Sci Human Life, Bunkyo Ku, Tokyo, Japan

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 07期

关键词：

leishmaniasis; pterosin; kaurene; diarylheptanoid; Betula; fern;

D O I：

10.1002/ptr.1502

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Leishmanicidal activity of 46 natural products including several fern and Betula constituents was examined. Several pterosin and atisene compounds from ferns had high activity. Among the triterpenoids the carboxyl group was found to be important for activity. In the diarytheptanoids, the linear-type and the diphenylethertype showed significant activity, and it was found that the carbonyl group at C-11 is necessary for the activity of biphenyl-types. Copyright (C) 2004 John Wiley Sons, Ltd.

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页码：573 / 578

页数：6

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