TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer

被引:23
作者
Fujii, Satoshi [1 ]
Fujihara, Ayano [1 ]
Natori, Kei [1 ]
Abe, Anna [1 ]
Kuboki, Yasutoshi [1 ]
Higuchi, Youichi [1 ]
Aizawa, Masaki [2 ]
Kuwata, Takeshi [1 ]
Kinoshita, Takahiro [3 ]
Yasui, Wataru [4 ]
Ochiai, Atsushi [1 ]
机构
[1] Natl Canc Ctr Hosp East, Natl Canc Ctr Kashiwa, Div Pathol, Res Ctr Innovat Oncol, Kashiwa, Chiba 2778577, Japan
[2] Niigata Canc Ctr Hosp, Dept Digest Surg, Chuou Ku, Niigata 9518566, Japan
[3] Natl Canc Ctr Hosp East, Dept Surg Oncol, Kashiwa, Chiba 2778577, Japan
[4] Hiroshima Univ, Dept Mol Pathol, Inst Biomed & Hlth Sci, Minami Ku, Hiroshima 7348551, Japan
关键词
Cancer stromal cell; cancer-associated fibroblast; gastric cancer; immunohistochemistry; TEM1; ENDOSIALIN TEM1; STROMAL FIBROBLASTS; MARKER; CELLS; PROGRESSION; SARCOMA; TUMORS;
D O I
10.1002/cam4.515
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM1 expression in CAFs or vessel-associated cells was determined using immunohistochemical staining. Three items (CAF-TEM1-positivity, CAF-TEM1-intensity, and vessel-TEM1-intensity) were then examined to determine the correlations between the TEM1 expression status and the recurrence-free survival (RFS), overall survival (OS), cancer-related survival (COS), and other clinicopathological factors. Significant correlations between CAF-TEM1-positivity or CAF-TEM1-intensity and RFS, OS, or COS were observed (P<0.001, Kaplan-Meier curves); however, no significant correlation between vessel-TEM1-intensity and RFS, OS, or COS was observed. A univariate analysis showed that CAF-TEM1-positivity and CAF-TEM1-intensity were each correlated with a scirrhous subtype, tumor depth, nodal status, distant metastasis, serosal invasion, lymphatic or venous vessel infiltrations, and pTMN stage. This study suggests that the inhibition of TEM1 expression specifically in the CAFs of gastric carcinoma might represent a new strategy for the treatment of gastric cancer.
引用
收藏
页码:1667 / 1678
页数:12
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