Pore modulation of zirconium-organic frameworks for high-efficiency detection of trace proteins

被引：131

作者：

Liu, Chun-Sen ^{[1
]}

Zhang, Zhi-Hong ^{[1
]}

Chen, Min ^{[1
]}

Zhao, Hui ^{[1
]}

Duan, Feng-He ^{[1
]}

Chen, Di-Ming ^{[1
]}

Wang, Ming-Hua ^{[1
]}

Zhang, Shuai ^{[1
]}

Du, Miao ^{[1
]}

机构：

[1] Zhengzhou Univ Light Ind, Henan Prov Key Lab Surface & Interface Sci, Zhengzhou 450002, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 28期

基金：

中国国家自然科学基金;

关键词：

FUNCTIONALIZATION; ADSORPTION; SPECTROSCOPY; APTASENSOR; STABILITY; BIOSENSOR; DESIGN;

D O I：

10.1039/c7cc00029d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tunable electrochemical biosensors based on analogous Zr-MOFs were developed for protein detection, the performances of which rely on the pore sizes and surroundings of the MOFs that show diverse binding behaviors to aptamers and then the targeted proteins. The optimized Zr-MOF-based sensor has high selectivity to lysozyme in a wide concentration range and a low detection limit of 3.6 pg mL(-1), with good repeatability, stability, and applicability in real samples. This work will establish a new platform for biosensing and extend the application scope of MOF materials.

引用

页码：3941 / 3944

页数：4

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