Identification of Major Metabolites of Salbutamol in Swine Urine and Plasma Using Ultra-High Performance Liquid Chromatography-Electrospray Time of Flight Mass Spectrometry

被引：8

作者：

Gu Xu ^{[1
]}

Liu Yi-Ming ^{[1
]}

Yao Ting ^{[1
]}

Shi Hua-Le ^{[1
]}

Li Jun ^{[1
]}

Zhao Zhen ^{[1
]}

Qin Yu-Chang ^{[2
]}

机构：

[1] Chinese Acad Agr Sci, Feed Res Inst, Beijing 100081, Peoples R China

[2] Minist MOA, Food & Nutr Dev Inst, Beijing 100081, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2014年 / 42卷 / 11期

关键词：

Salbutamol; Ultra-high performance liquid chromatography-electrospray time of flight mass spectrometry; Metabolites; VIVO FORMATION; IN-VIVO; CLENBUTEROL; ENANTIOMERS;

D O I：

10.1016/S1872-2040(14)60784-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The excretion of urinary and plasmic metabolites of salbutamol was studied using ultra performance liquid chromatography electrospray ionization quadrupole time-of-flight tandem mass spectrometry, after a single intragastric gavaged dose administration with salbutamol. The software of Agilent Mass Hunter Metabolite ID was employed to find and identify the chemical structure of metabolites of salbutamol. Five metabolites from salbutamol were identified. The metabolites identified in swine urine included glucuronide conjugate salbutamol, N-oxide-salbutamol, hydroxyl-salbutamol, methoxyl-salbutamol and dehydrated hydroxyl-salbutamol. Whereas, only the parent drugs, glucuronide conjugate salbutamol and N-oxide salbutamol were observed in plasma.

引用

页码：1692 / 1696

页数：5

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