Self-assembled signaling aptamer DNA arrays for protein detection

被引：129
作者：
Lin, Chenxiang
Katilius, Evaldas
Liu, Yan
Zhang, Junping
Yan, Hao [1 ]
机构：
[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 32期
关键词：
DNA arrays; molecular recognition; protein detection; self-assembly; signaling aptamers;
D O I：
10.1002/anie.200600438
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5296 / 5301
页数：6
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