The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma

被引：1
作者：
Gkioka, Eliona [1 ]
Msaouel, Pavlos [2 ]
Philippou, Anastassios [1 ]
Vlachogiannis, Nikolaos I. [1 ]
Vogkou, Christiana T. [1 ]
Margiolis, Argyris [3 ]
Koutsilieris, Michael [1 ]
机构：
[1] Univ Athens, Dept Expt Physiol, Sch Med, Athens 11527, Greece
[2] Albert Einstein Coll Med, Jacobi Med Ctr, Bronx, NY 10467 USA
[3] Natl Hlth Syst, Areopolis, Greece
来源：
IN VIVO | 2015年 / 29卷 / 06期
关键词：
Leiomyomas; IGFs; estrogen receptor; progesterone receptor; review; ESTROGEN-RECEPTOR-ALPHA; IGF-BINDING-PROTEINS; MGF E-PEPTIDE; MESSENGER-RNA EXPRESSION; HORMONE REPLACEMENT THERAPY; PROSTATE-CANCER CELLS; SMOOTH-MUSCLE TISSUES; GENE-EXPRESSION; HUMAN MYOMETRIUM; FACTOR SYSTEM;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.
引用
收藏
页码：637 / 649
页数：13
相关论文
共 164 条
[21]  
Brisson BK, PLOS ONE, V72012
[22]  
Brisson BK, FRONT ENDOCRINOL, P42013
[23]   Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways [J].
Bulayeva, NN ;
Watson, CS .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (15) :1481-1487
[24]   Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat [J].
Burroughs, KD ;
Fuchs-Young, R ;
Davis, B ;
Walker, CL .
BIOLOGY OF REPRODUCTION, 2000, 63 (05) :1322-1330
[25]   Dysregulation of IGF-I signaling in uterine leiomyoma [J].
Burroughs, KD ;
Howe, SR ;
Okubo, Y ;
Fuchs-Young, R ;
LeRoith, D ;
Walker, CL .
JOURNAL OF ENDOCRINOLOGY, 2002, 172 (01) :83-93
[26]   The phosphoinositide 3-kinase pathway [J].
Cantley, LC .
SCIENCE, 2002, 296 (5573) :1655-1657
[27]   Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology [J].
Catherino, WH ;
Prupas, C ;
Tsibris, JCM ;
Leppert, PC ;
Payson, M ;
Nieman, LK ;
Segars, JH .
FERTILITY AND STERILITY, 2003, 80 (02) :282-290
[28]   AN ALTERNATIVELY SPLICED HUMAN INSULIN-LIKE GROWTH-FACTOR-I TRANSCRIPT WITH HEPATIC TISSUE EXPRESSION THAT DIVERTS AWAY FROM THE MITOGENIC IBE1 PEPTIDE [J].
CHEW, SL ;
LAVENDER, P ;
CLARK, AJL ;
ROSS, RJM .
ENDOCRINOLOGY, 1995, 136 (05) :1939-1944
[29]   Distinct Alterations in Chromatin Organization of the Two IGF-I Promoters Precede Growth Hormone-Induced Activation of IGF-I Gene Transcription [J].
Chia, Dennis J. ;
Young, Jennifer J. ;
Mertens, April R. ;
Rotwein, Peter .
MOLECULAR ENDOCRINOLOGY, 2010, 24 (04) :779-789
[30]  
Christopoulos PF, 2015, ANTICANCER RES, V35, P107
12345678910