The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma

被引：1

作者：

Gkioka, Eliona ^{[1
]}

Msaouel, Pavlos ^{[2
]}

Philippou, Anastassios ^{[1
]}

Vlachogiannis, Nikolaos I. ^{[1
]}

Vogkou, Christiana T. ^{[1
]}

Margiolis, Argyris ^{[3
]}

Koutsilieris, Michael ^{[1
]}

机构：

[1] Univ Athens, Dept Expt Physiol, Sch Med, Athens 11527, Greece

[2] Albert Einstein Coll Med, Jacobi Med Ctr, Bronx, NY 10467 USA

[3] Natl Hlth Syst, Areopolis, Greece

来源：

IN VIVO | 2015年 / 29卷 / 06期

关键词：

Leiomyomas; IGFs; estrogen receptor; progesterone receptor; review; ESTROGEN-RECEPTOR-ALPHA; IGF-BINDING-PROTEINS; MGF E-PEPTIDE; MESSENGER-RNA EXPRESSION; HORMONE REPLACEMENT THERAPY; PROSTATE-CANCER CELLS; SMOOTH-MUSCLE TISSUES; GENE-EXPRESSION; HUMAN MYOMETRIUM; FACTOR SYSTEM;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.

引用

页码：637 / 649

页数：13

共 164 条

[1] INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC-ACIDS WITH ALTERNATIVE 5'-UNTRANSLATED REGIONS ARE DIFFERENTIALLY EXPRESSED DURING DEVELOPMENT OF THE RAT [J].

ADAMO, M ;

LOWE, WL ;

LEROITH, D ;

ROBERTS, CT .

ENDOCRINOLOGY, 1989, 124 (06) :2737-2744

[2] TRANSCRIPTION INITIATION IN THE 2 LEADER EXONS OF THE RAT IGF-I GENE OCCURS FROM DISPERSE VERSUS LOCALIZED SITES [J].

ADAMO, ML ;

BENHUR, H ;

LEROITH, D ;

ROBERTS, CT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (02) :887-893

[3] DISTINCT PROMOTERS IN THE RAT INSULIN-LIKE GROWTH FACTOR-I (IGF-I) GENE ARE ACTIVE IN CHO CELLS [J].

ADAMO, ML ;

LANAU, F ;

NEUENSCHWANDER, S ;

WERNER, H ;

LEROITH, D ;

ROBERTS, CT .

ENDOCRINOLOGY, 1993, 132 (02) :935-937

[4] Growth factors and cytokines in uterine leiomyomas [J].

Andersen, J .

SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1996, 14 (03) :269-282

[5] Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH [J].

Aperghis, Michael ;

Velloso, Cristiana P. ;

Hameed, Mahjabeen ;

Brothwood, Theresa ;

Bradley, Lloyd ;

Bouloux, Pierre M. G. ;

Harridge, Stephen D. R. ;

Goldspink, Geoffrey .

GROWTH HORMONE & IGF RESEARCH, 2009, 19 (01) :61-67

[6] Oncogenic Role of the Ec Peptide of the IGF-1Ec Isoform in Prostate Cancer [J].

Armakolas, Athanasios ;

Kaparelou, Maria ;

Dimakakos, Andreas ;

Papageorgiou, Efstathia ;

Armakolas, Nikolaos ;

Antonopoulos, Athanasios ;

Petraki, Constantina ;

Lekarakou, Maria ;

Lelovas, Pavlos ;

Stathaki, Martha ;

Psarros, Constantinos ;

Donta, Ismene ;

Galanos, Panos S. ;

Msaouel, Paul ;

Gorgoulis, Vassilis G. ;

Koutsilieris, Michael .

MOLECULAR MEDICINE, 2015, 21 :167-179

[7] Preferential Expression of IGF-1Ec (MGF) Transcript in Cancerous Tissues of Human Prostate: Evidence for a Novel and Autonomous Growth Factor Activity of MGF E Peptide in Human Prostate Cancer Cells [J].

Armakolas, Athanasios ;

Philippou, Anastassios ;

Panteleakou, Zacharoula ;

Nezos, Adrianos ;

Sourla, Antigone ;

Petraki, Constantina ;

Koutsilieris, Michael .

PROSTATE, 2010, 70 (11) :1233-1242

[8] The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle [J].

Ates, Kenan ;

Yang, Shi Yu ;

Orrell, Richard W. ;

Sinanan, Andrea C. M. ;

Simons, Paul ;

Solomon, Andrew ;

Beech, Steven ;

Goldspink, Geoffrey ;

Lewis, Mark P. .

FEBS LETTERS, 2007, 581 (14) :2727-2732

[9]

Barbarisi A, 2001, J CELL PHYSIOL, V186, P414, DOI 10.1002/1097-4652(2000)9999:999<000::AID-JCP1040>3.0.CO

[10]

2-E

← 1 2 3 4 5 6 7 8 9 10 →