Peptide profiling of cerebrospinal fluid by mass spectrometry

被引：12
作者：
Dekker, Lennard J.
Burgers, Peter C.
Kros, Johan M.
Smitt, Peter A. E. Sillevis
Luider, Theo M.
机构：
[1] Erasmus Univ, Med Ctr, Dept Neurol, Lab Neurooncol, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Pathol, NL-3000 DR Rotterdam, Netherlands
来源：
EXPERT REVIEW OF PROTEOMICS | 2006年 / 3卷 / 03期
关键词：
biomarker; proteomics; MALDI-FT ion cyclotron resonance; MALDI-TOF; mass spectrometry; peptide profiling;
D O I：
10.1586/14789450.3.3.297
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The search for biomarkers is driven by the increasing clinical importance of early diagnosis. Reliable biomarkers can also assist in directing therapy, monitoring disease activity and the efficacy of treatment. In addition, the discovery of novel biomarkers might provide clues to the pathogenesis of a disease. The dynamic range of protein concentrations in body fluids exceeds 10 orders of magnitude. These huge differences in concentrations complicate the detection of proteins with low expression levels. Since all classical biomarkers have low expression levels (e.g., prostate-specific antigen: 2-4 mu g/l; and CA125: 20-35 U/ml), new developments with respect to identification and validation techniques of the low-abundance proteins are required. This review will discuss the current status of profiling cerebrospinal fluid using mass spectrometry-based techniques, and new developments in this area.
引用
收藏
页码：297 / 309
页数：13
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