Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes
被引:30
作者:
Silverman, Anna L.
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机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Silverman, Anna L.
[1
,2
]
Hammel, Naama
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机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Hammel, Naama
[1
]
Khachatryan, Naira
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h-index: 0
机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Khachatryan, Naira
[1
]
Sharpsten, Lucie
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机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Sharpsten, Lucie
[1
]
Medeiros, Felipe A.
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机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Medeiros, Felipe A.
[1
]
Girkin, Christopher A.
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机构:
Univ Alabama Birmingham, Sch Med, Birmingham, AL USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Girkin, Christopher A.
[3
]
Liebmann, Jeffrey M.
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机构:
Columbia Univ, Med Ctr, Harkness Eye Inst, New York, NY USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Liebmann, Jeffrey M.
[4
]
Weinreb, Robert N.
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h-index: 0
机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Weinreb, Robert N.
[1
]
Zangwill, Linda M.
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Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
Zangwill, Linda M.
[1
]
机构:
[1] Univ Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USA
[2] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA
[3] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA
[4] Columbia Univ, Med Ctr, Harkness Eye Inst, New York, NY USA
Purpose: To evaluate and compare the diagnostic accuracy of global and sector analyses for detection of early visual field (VF) damage using the retinal nerve fiber layer (RNFL) reference databases of the Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD OCT) devices. Methods: Healthy subjects and glaucoma suspects from the Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES) with at least 2 years of follow-up were included. Global and sectoral RNFL measures were classified as within normal limits, borderline (BL), and outside normal limits (ONL) on the basis of the device reference databases. The sensitivity of ONL classification was estimated in glaucoma suspect eyes that developed repeatable VF damage. Results: A total of 353 glaucoma suspect eyes and 279 healthy eyes were included. A total of 34 (9.6%) of the glaucoma suspect eyes developed VF damage. In glaucoma suspect eyes, Spectralis and Cirrus ONL classification was present in 47 eyes (13.3%) and 24 eyes (6.8%), respectively. The sensitivity of the global RNFL ONL classification among eyes that developed VF damage was 23.5% for Cirrus and 32.4% for Spectralis. The specificity of within-normal-limits global classification in healthy eyes was 100% for Cirrus and 99.6% for Spectralis. There was moderate to substantial agreement between Cirrus and Spectralis classification as ONL. Conclusions: The Spectralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good agreement for detection of eyes with early glaucoma damage. (C) 2016 by the American Academy of Ophthalmology.
机构:
UAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Girkin, Christopher A.
;
Liebmann, Jeffery
论文数: 0引用数: 0
h-index: 0
机构:
Vet Adm Harbor Healthcare Syst, Brooklyn, NY USA
New York Eye & Ear Infirm, New York, NY 10003 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Liebmann, Jeffery
;
Fingeret, Murray
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Fingeret, Murray
;
Greenfield, David S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Greenfield, David S.
;
Medeiros, Felipe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
机构:
Korea Univ, Coll Med, Dept Ophthalmol, Seoul 136705, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
Kim, Yong Yeon
;
Kim, Hwang Ki
论文数: 0引用数: 0
h-index: 0
机构:
Konyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
Kim, Hwang Ki
;
Sohn, Yong Ho
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机构:
Konyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Jeoung, Jin Wook
;
Kim, Tae-Woo
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机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ, Dept Ophthalmol, Bundang Hosp, Songnam 463707, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Kim, Tae-Woo
;
Weinreb, Robert N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USASeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Weinreb, Robert N.
;
Kim, Seok Hwan
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h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ, Dept Ophthalmol, Boramae Hosp, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Kim, Seok Hwan
;
Park, Ki Ho
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机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Park, Ki Ho
;
Kim, Dong Myung
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机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Kim, Na Rae
;
Lee, Eun Suk
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Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Lee, Eun Suk
;
Seong, Gong Je
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Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Seong, Gong Je
;
Choi, Eun Hee
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机构:
Yonsei Univ, Coll Med, Dept Biostat, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Choi, Eun Hee
;
Hong, Samin
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机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Hong, Samin
;
Kim, Chan Yun
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h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
机构:
UAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Girkin, Christopher A.
;
Liebmann, Jeffery
论文数: 0引用数: 0
h-index: 0
机构:
Vet Adm Harbor Healthcare Syst, Brooklyn, NY USA
New York Eye & Ear Infirm, New York, NY 10003 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Liebmann, Jeffery
;
Fingeret, Murray
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Fingeret, Murray
;
Greenfield, David S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
Greenfield, David S.
;
Medeiros, Felipe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USAUAB, Dept Ophthalmol, Sch Med, Birmingham, AL 35233 USA
机构:
Korea Univ, Coll Med, Dept Ophthalmol, Seoul 136705, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
Kim, Yong Yeon
;
Kim, Hwang Ki
论文数: 0引用数: 0
h-index: 0
机构:
Konyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
Kim, Hwang Ki
;
Sohn, Yong Ho
论文数: 0引用数: 0
h-index: 0
机构:
Konyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South KoreaKonyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol, Seoul, South Korea
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Jeoung, Jin Wook
;
Kim, Tae-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ, Dept Ophthalmol, Bundang Hosp, Songnam 463707, Gyeonggi Do, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Kim, Tae-Woo
;
Weinreb, Robert N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Hamilton Glaucoma Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USASeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Weinreb, Robert N.
;
Kim, Seok Hwan
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ, Dept Ophthalmol, Boramae Hosp, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Kim, Seok Hwan
;
Park, Ki Ho
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h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Park, Ki Ho
;
Kim, Dong Myung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul 110744, South KoreaSeoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Kim, Na Rae
;
Lee, Eun Suk
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Lee, Eun Suk
;
Seong, Gong Je
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Seong, Gong Je
;
Choi, Eun Hee
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Biostat, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Choi, Eun Hee
;
Hong, Samin
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea
Hong, Samin
;
Kim, Chan Yun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Ophthalmol, Inst Vis Res, Seoul 120752, South Korea