The WAVE regulatory complex is inhibited

被引：116
作者：
Ismail, Ayman M.
Padrick, Shae B.
Chen, Baoyu
Umetani, Junko
Rosen, Michael K. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 05期
基金：
美国国家卫生研究院;
关键词：
ACTIVATION; CYTOSKELETON; RAC;
D O I：
10.1038/nsmb.1587
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.
引用
收藏
页码：561 / 563
页数：3
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