Localization of amyloid beta (Aβ1-42) protofibrils in membrane lateral compartments: Effect of cholesterol and 7-Ketocholesterol

被引：9
|
作者：
Phan, Huong T. T. [1 ,2 ]
Vestergaard, Mun'delanji C. [1 ]
Baek, KeangOk [1 ]
Shimokawa, Naofumi [1 ]
Takagi, Masahiro [1 ]
机构：
[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Nomi, Ishikawa 9231292, Japan
[2] Hanoi Natl Univ Educ, Hanoi, Vietnam
来源：
FEBS LETTERS | 2014年 / 588卷 / 18期
基金：
日本学术振兴会;
关键词：
Cholesterol; 7-Ketocholesterol; Amyloid beta localization; Membrane lateral compartments; Membrane fluidity; ALZHEIMERS-DISEASE; PEPTIDE; PROTEIN; DOMAINS; MODEL; TRANSFORMATION; PATHWAYS; VESICLES; BILAYERS; RAFTS;
D O I：
10.1016/j.febslet.2014.08.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cholesterol plays an important role in the interaction of Alzheimer's amyloid beta (A beta) with cell membranes, an important event in A beta-induced cytotoxicity. However, it is not fully understood how cholesterol influences the association of Ab with membrane lateral compartments. We have shown that by modulating membrane fluidity, cholesterol decreased peptide localization in solid-ordered domains and increased that in liquid-ordered domains. It changed the amount of A beta associating with liquid-disordered (Ld) phase with different tendencies depending on the composition of heterogeneous membrane systems. 7-Ketocholesterol, an oxidized derivative of cholesterol, majorly enhanced the fluidity of and A beta interaction with Ld phase. These findings are useful for clarifying the impact of cholesterol and its oxidation in A beta-induced toxicity. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3483 / 3490
页数：8
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