Inflammatory Mediators in Chinese Patients With Congestive Heart Failure

被引：16

作者：

Wang, Yongqing ^{[1
]}

Zhou, Yanli ^{[1
]}

Meng, Ling ^{[1
]}

Lu, Xinzheng ^{[1
]}

Ou, Ning ^{[1
]}

Li, Xinli ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Peoples R China

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2009年 / 49卷 / 05期

关键词：

Heart failure; TNF-alpha; interleukin-10; interleukin-6; BNP; NECROSIS-FACTOR-ALPHA; REGULATING OXIDATIVE STRESS; TNF-ALPHA; IL-10; INTERPLAY;

D O I：

10.1177/0091270009333265

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New York Heart Association (NYHA) class show higher concentrations of inflammatory mediators than those in a lower NYHA class, although the ratio of plasma IL-10 to TNF-alpha in patients with CHF is significantly lower than in the control group. It is concluded that proinflammatory and anti-inflammatory cytokine levels are increased and IL-10/TNF-alpha is decreased in Chinese patients with CHF. In this study, circulating levels of proinflammatory and anti-inflammatory mediators are studied in patients with chronic heart failure (CHF) in China. Sixty-five patients with CHF and 32 control subjects are studied. The proinflammatory and anti-inflammatory cytokines interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) in plasma are determined by immunoradiometric assay kits. Catecholamine (CA) in plasma is evaluated by high-performance liquid chromatography. Plasma levels of IL-6, IL-10, TNF-a, ANP, BNP, and CA in CHF patients are significantly higher than those in control subjects. Patients in a higher

引用

页码：591 / 599

页数：9

共 23 条

[1] Anti-tumour necrosis factor-α therapy in heart failure:: Future directions [J].

Balakumar, Pitchai ;

Singh, Manjeet .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2006, 99 (06) :391-397

[2] NT-proBNP and BNP: biomarkers for heart failure management [J].

Bettencourt, P .

EUROPEAN JOURNAL OF HEART FAILURE, 2004, 6 (03) :359-363

[3] Role of apoptosis in ventricular remodeling. [J].

Chandrashekhar Y. .

Current Heart Failure Reports, 2005, 2 (1) :18-22

[4] Comparing Type D personality and older age as correlates of tumor necrosis factor-α dysregulation in chronic heart failure [J].

Denollet, Johan ;

Vrints, Christiaan J. ;

Conraads, Viviane M. .

BRAIN BEHAVIOR AND IMMUNITY, 2008, 22 (05) :736-743

[5] p38 and ERK1/2 MAPKs mediate the interplay of TNF-α and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis [J].

Dhingra, Sanjiv ;

Sharma, Anita K. ;

Singla, Dinender K. ;

Singal, Pawan K. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (06) :H3524-H3531

[6] Cytokines and myocardial dysfunction: State of the art [J].

El-Menyar, Ayman A. .

JOURNAL OF CARDIAC FAILURE, 2008, 14 (01) :61-74

[7] Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches [J].

Gullestad, L ;

Aukrust, P .

AMERICAN JOURNAL OF CARDIOLOGY, 2005, 95 (11A) :17C-23C

[8] Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy [J].

Hong, Y ;

Hui, SSC ;

Chan, BTY ;

Hou, JY .

LIFE SCIENCES, 2003, 72 (22) :2499-2507

[9]

JOCHEM H, 2005, EUR J HEART FAIL, V7, P81

[10] Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction [J].

Kaur, K. ;

Sharma, A. K. ;

Singal, P. K. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (01) :H106-H113

← 1 2 3 →