Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N-Acetyl-2-aminobiaryls through Regioselective C-H Bond Activation

被引：18

作者：

Annamalai, Pratheepkumar ^{[1
]}

Hsu, Kou-Chi ^{[1
]}

Raju, Selvam ^{[1
]}

Hsiao, Huan-Chang ^{[1
]}

Chou, Chih-Wei ^{[1
]}

Lin, Gu-Ying ^{[1
]}

Hsieh, Cheng-Ming ^{[1
]}

Chen, Pei-Ling ^{[2
]}

Liu, Yi-Hung ^{[3
]}

Chuang, Shih-Ching ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30013, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

[3] Natl Taiwan Univ, Instrumentat Ctr, Taipei 30010, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 07期

关键词：

ONE-POT SYNTHESIS; DIRECTING-GROUP; O-ARYLANILINES; ARYL IODIDES; ANNULATION; ARYLATION; INDOLES; ALKYNES; OLEFINATION; ALKYLATION;

D O I：

10.1021/acs.joc.8b00194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C-H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins.

引用

收藏

页码：3840 / 3856

页数：17

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