Anthoxanthin Polyphenols Attenuate A Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease
被引:32
作者:
Pate, Kayla M.
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Univ South Carolina, Dept Chem Engn, Columbia, SC USA
Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
Pate, Kayla M.
[1
,3
]
Rogers, McCall
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机构:
Univ South Carolina, Dept Chem Engn, Columbia, SC USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
Rogers, McCall
[1
]
Reed, John Will
论文数: 0引用数: 0
h-index: 0
机构:
Univ South Carolina, Dept Chem Engn, Columbia, SC USA
Home Depot, Data Analyt, Atlanta, GA 30318 USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
Reed, John Will
[1
,4
]
van der Munnik, Nicholas
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机构:
Univ South Carolina, Dept Chem Engn, Columbia, SC USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
van der Munnik, Nicholas
[1
]
Vance, Steven Zebulon
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Univ South Carolina, Biomed Engn Program, Columbia, SC USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
Vance, Steven Zebulon
[2
]
Moss, Melissa A.
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机构:
Univ South Carolina, Dept Chem Engn, Columbia, SC USA
Univ South Carolina, Biomed Engn Program, Columbia, SC USAUniv South Carolina, Dept Chem Engn, Columbia, SC USA
Moss, Melissa A.
[1
,2
]
机构:
[1] Univ South Carolina, Dept Chem Engn, Columbia, SC USA
[2] Univ South Carolina, Biomed Engn Program, Columbia, SC USA
[3] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA
[4] Home Depot, Data Analyt, Atlanta, GA 30318 USA
AimsEpidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid- (A) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. MethodsAnthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action. ResultsWhile modulation of oligomerization resulted in only minor reductions to neuronal responses, anthoxanthin antioxidant action significantly attenuated oligomer-induced intracellular ROS and caspase activation. Kaempferol uniquely exhibited synergism when the two mechanisms functioned in concert, leading to a pronounced reduction in both ROS and caspase activation. ConclusionsTogether, these findings identify the dominant mechanism by which these anthoxanthins attenuate A oligomer-induced neuronal responses, elucidate their prospective synergy, and demonstrate the potential of anthoxanthin polyphenols as natural AD therapeutics.
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Akaishi, Tatsuhiro
Morimoto, Takeo
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机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Morimoto, Takeo
Shibao, Mami
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h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Shibao, Mami
Watanabe, Sayaka
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h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Watanabe, Sayaka
Sakai-Kato, Kumiko
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机构:
Musashino Univ, Phys Chem Lab, Fac Pharm, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Sakai-Kato, Kumiko
Utsunomiya-Tate, Naoko
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机构:
Musashino Univ, Phys Chem Lab, Fac Pharm, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Utsunomiya-Tate, Naoko
Abe, Kazuho
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h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Ansari, Mubeen Ahmad
Abdul, Hafiz Mohammad
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机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Abdul, Hafiz Mohammad
Joshi, Gururaj
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机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Joshi, Gururaj
Opii, Wycliffe O.
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机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Opii, Wycliffe O.
Butterfield, D. Allan
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机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Akaishi, Tatsuhiro
Morimoto, Takeo
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Morimoto, Takeo
Shibao, Mami
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Shibao, Mami
Watanabe, Sayaka
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Watanabe, Sayaka
Sakai-Kato, Kumiko
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Phys Chem Lab, Fac Pharm, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Sakai-Kato, Kumiko
Utsunomiya-Tate, Naoko
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Phys Chem Lab, Fac Pharm, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Utsunomiya-Tate, Naoko
Abe, Kazuho
论文数: 0引用数: 0
h-index: 0
机构:
Musashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, JapanMusashino Univ, Pharmacol Lab, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Ansari, Mubeen Ahmad
Abdul, Hafiz Mohammad
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Abdul, Hafiz Mohammad
Joshi, Gururaj
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Joshi, Gururaj
Opii, Wycliffe O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA
Opii, Wycliffe O.
Butterfield, D. Allan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40506 USA
Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USAUniv Kentucky, Dept Chem, Lexington, KY 40506 USA