A Simple and Precise Determination of Diltiazem Hydrochloride by Simultaneous Conductometric and Potentiometric Detection

被引：1
|
作者：
de Noronha, Barbara Viero [1 ]
Poletti Papi, Mauricio Alberto [1 ]
Bergamini, Marcio Fernando [1 ]
Marcolino-Junior, Luiz Humberto [1 ]
机构：
[1] Univ Fed Parana, Lab Electrochem Sensors, Dept Chem, BR-19081 Curitiba, Parana, Brazil
来源：
CURRENT PHARMACEUTICAL ANALYSIS | 2014年 / 10卷 / 03期
关键词：
Conductometric titration; potentiometric titration; diltiazem determination; PHARMACEUTICAL FORMULATIONS; TITRANT; SYSTEM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present work proposes a simple, accurate and low-cost method employing simultaneous detection (conductometric and potentiometric) during a precipitation titration using silver nitrate as titrant for diltiazem hydrochloride (DTZ) determination. Both methods were based on the chemical reaction between chloride ions coming from diltiazem hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The conductance of the solution and the electric potential of the cell (using an Ag-wire electrode) were measured as a function of the volume of titrant. Under optimized experimental conditions the method was applied for DTZ determination in pharmaceuticals and the results obtained are in close agreement with those obtained using an official method proposed by the British Pharmacopoeia.
引用
收藏
页码：203 / 207
页数：5
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