A Simple and Precise Determination of Diltiazem Hydrochloride by Simultaneous Conductometric and Potentiometric Detection

被引：1
|
作者：
de Noronha, Barbara Viero [1 ]
Poletti Papi, Mauricio Alberto [1 ]
Bergamini, Marcio Fernando [1 ]
Marcolino-Junior, Luiz Humberto [1 ]
机构：
[1] Univ Fed Parana, Lab Electrochem Sensors, Dept Chem, BR-19081 Curitiba, Parana, Brazil
来源：
CURRENT PHARMACEUTICAL ANALYSIS | 2014年 / 10卷 / 03期
关键词：
Conductometric titration; potentiometric titration; diltiazem determination; PHARMACEUTICAL FORMULATIONS; TITRANT; SYSTEM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present work proposes a simple, accurate and low-cost method employing simultaneous detection (conductometric and potentiometric) during a precipitation titration using silver nitrate as titrant for diltiazem hydrochloride (DTZ) determination. Both methods were based on the chemical reaction between chloride ions coming from diltiazem hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The conductance of the solution and the electric potential of the cell (using an Ag-wire electrode) were measured as a function of the volume of titrant. Under optimized experimental conditions the method was applied for DTZ determination in pharmaceuticals and the results obtained are in close agreement with those obtained using an official method proposed by the British Pharmacopoeia.
引用
收藏
页码：203 / 207
页数：5
相关论文
共 50 条
  • [1] A Fast and Simple Conductometric Method for Verapamil Hydrochloride Determination in Pharmaceutical Formulations
    Caetano, Fabio R.
    Gevaerd, Ava
    Bergamini, Marcio F.
    Marcolino-Junior, Luiz H.
    CURRENT PHARMACEUTICAL ANALYSIS, 2011, 7 (04) : 275 - 279
  • [2] CONDUCTOMETRIC DETERMINATION OF TETRACYCLINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
    Goes Junior, Enock Jose A.
    Roeder, Jakson S.
    da Silva, Jonatas G.
    QUIMICA NOVA, 2017, 40 (08): : 952 - 956
  • [3] Methodology Development for Combined Determination of Vitamins Thiamine (di-Hydrochloride) and Pyridoxine (Hydrochloride) in Aqueous Solutions and Pharmaceutical Samples by Potentiometric and Conductometric Titrations
    Amaral, Eros Izidoro
    da Silva Vaz, Glaucia Carla
    Teixeir, Marco Antonio G.
    REVISTA VIRTUAL DE QUIMICA, 2015, 7 (05) : 1766 - 1779
  • [4] Potentiometric and conductometric determination of TOC in water samples
    Stefanska, W
    Rubel, S
    CHEMIA ANALITYCZNA, 1996, 41 (06): : 1015 - 1023
  • [5] Conductometric Determination of Dropropizine and Tizanidine Hydrochloride in their Pharmaceutical Formulations
    Elwy, Hanan M.
    Abdel-Moaty, Mona M.
    Abdel-Hamid, Safaa M.
    ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY, 2015, 7 (01): : 105 - 117
  • [6] Determination of Diltiazem Hydrochloride using Paperbased ECL sensor
    Torul, Hilal
    JOURNAL OF RESEARCH IN PHARMACY, 2022, 26 (05): : 1472 - 1483
  • [7] Simultaneous Determination of Ba(OH)(2) Content by Conductometric and Potentiometric Titration: A Suggestion of an Experiment to Eletrochemical Teaching in Instrumental Analysis
    Amaral, Eros Izidoro
    Teixeira, Marco Antonio G.
    REVISTA VIRTUAL DE QUIMICA, 2015, 7 (05) : 1866 - 1875
  • [8] Conductometric and Potentiometric Determination of Acetylsalicylic Acid in Aspirin (R) : A Suggestion for an Experimental Activity for the Instrumental Analysis
    de Sousa, Aurilene G.
    das Chagas, Franklin W. M.
    Gois, Lucas de C.
    da Silva, Jonatas G.
    REVISTA VIRTUAL DE QUIMICA, 2018, 10 (03) : 502 - 517
  • [9] Simultaneous determination of mixtures of acids by potentiometric titration
    Ni, YN
    ANALYTICA CHIMICA ACTA, 1998, 367 (1-3) : 145 - 152
  • [10] Indirect spectrophotometric determination of diltiazem hydrochloride in pure form and pharmaceutical formulations
    El-Didamony, AM
    CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 2005, 3 (03): : 520 - 536
12345