Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

被引：13

作者：

Obon-Santacana, Mireia ^{[1
]}

Lujan-Barroso, Leila ^{[1
]}

Freisling, Heinz ^{[2
]}

Cadeau, Claire ^{[3
,4
,5
]}

Fagherazzi, Guy ^{[3
,4
,5
]}

Boutron-Ruault, Marie-Christine ^{[3
,4
,5
]}

Kaaks, Rudolf ^{[6
]}

Fortner, Renee T. ^{[6
]}

Boeing, Heiner ^{[7
]}

Quiros, J. Ramon ^{[8
]}

Molina-Montes, Esther ^{[9
,10
]}

Chamosa, Saioa ^{[11
]}

Castano, Jose Maria Huerta ^{[10
,12
]}

Ardanaz, Eva ^{[10
,13
]}

Khaw, Kay-Tee ^{[14
]}

Wareham, Nick ^{[15
]}

Key, Tim ^{[16
]}

Trichopoulou, Antonia ^{[17
,18
]}

Lagiou, Pagona ^{[19
,20
]}

Naska, Androniki ^{[17
,19
]}

Palli, Domenico ^{[21
]}

Grioni, Sara ^{[22
]}

Tumino, Rosario ^{[23
,24
]}

Vineis, Paolo ^{[25
,26
]}

De Magistris, Maria Santucci ^{[27
]}

Bueno-de-Mesquita, H. B. ^{[26
,28
,29
,30
]}

Peeters, Petra H. ^{[26
,31
]}

Wennberg, Maria ^{[32
]}

Bergdahl, Ingvar A. ^{[33
]}

Vesper, Hubert ^{[34
]}

Riboli, Elio ^{[26
]}

Duell, Eric J. ^{[1
]}

机构：

[1] Bellvitge Biomed Res Inst ICO IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Program, Unit Nutr & Canc, Avda Gran Via Barcelona 199-203, Barcelona 08908, Spain

[2] Int Agcy Res Canc, Dietary Exposure Assessment Grp, 150 Cours Albert Thomas, F-69372 Lyon, France

[3] INSERM, U1018, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, F-94805 Villejuif, France

[4] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France

[5] Inst Gustave Roussy, F-94805 Villejuif, France

[6] German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 581, D-69120 Heidelberg, Germany

[7] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[8] Publ Hlth & Participat Directorate, Ciriaco Miguel Vigil 9, Asturias 33009, Spain

[9] Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Hosp Univ Granada,Cuesta Observ, 4 Campus Univ Cartuja, Granada 18080, Spain

[10] CIBER Epidemiol & Publ Hlth CIBERESP, Melchor Fernandez Almagro 3-5, Madrid 28029, Spain

[11] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa BIODONOSTIA, Avda Navarra 4, San Sebastian 20013, Spain

[12] Murcia Reg Hlth Author, Dept Epidemiol, Ronda de Levante 11, Murcia 30008, Spain

[13] Navarre Publ Hlth Inst, Pamplona 31012, Spain

[14] Univ Cambridge, Sch Clin Med, Robinson Way, Cambridge CB2 0SR, England

[15] Univ Cambridge, MRC, Epidemiol Unit, 184 Hills Rd, Cambridge CB2 8PQ, England

[16] Univ Oxford, Canc Epidemiol Unit, Old Rd Campus, Oxford OX3 7LF, England

[17] Hellen Hlth Fdn, 13 Kaisareias St, Athens 11527, Greece

[18] Acad Athens, Bur Epidemiol Res, 23 Alexandroupoleos St, Athens 11527, Greece

[19] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, 75 M Asias St, Athens 11527, Greece

[20] Harvard Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA

[21] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Via Oblate 2, I-50141 Florence, Italy

[22] Fdn IRCSS Ist Nazl Tumori, Epidemiol & Prevent Unit, Via Venezian 1, I-20133 Milan, Italy

[23] Civ MP Arezzo Hosp, Canc Registry, Via Civile, I-97100 Ragusa, Italy

[24] Civ MP Arezzo Hosp, Histopathol Unit, Via Civile, I-97100 Ragusa, Italy

[25] Human Genet Fdn HuGeF, Via Nizza 52, I-10126 Turin, Italy

[26] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, Norfolk Pl, London W2 1PG, England

[27] Univ Naples Federico II, Dept Clin & Expt Med, Corso Umberto 1,40Bis, I-80138 Naples, Italy

[28] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, POB 1, NL-3720 BA Bilthoven, Netherlands

[29] Univ Med Ctr, Dept Gastroenterol & Hepatol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[30] Univ Malaya, Fac Med, Dept Social & Prevent Med, Jalan Univ, Kuala Lumpur 50603, Wilayah Perseku, Malaysia

[31] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Huispost Str 6-131, NL-3508 GA Utrecht, Netherlands

[32] Umea Univ, Dept Publ Hlth & Clin Med, 1A,9 Tr,Kirurgctr 952, S-90185 Umea, Sweden

[33] Umea Univ, Dept Biobank Res, 1A,9 Tr,Kirurgctr 952, S-90185 Umea, Sweden

[34] Ctr Dis Control & Prevent, MS F25,4770 Buford Hwy NE, Atlanta, GA 30341 USA

来源：

EUROPEAN JOURNAL OF NUTRITION | 2017年 / 56卷 / 03期

基金：

英国医学研究理事会;

关键词：

Acrylamide; Glycidamide; Hemoglobin adducts; Biomarkers; Diet; Nutrition; FOOD FREQUENCY QUESTIONNAIRE; CANCER-RISK; EXPOSURE; MODEL; BIOMARKERS; ASSOCIATIONS; VALIDITY; SMOKING; WORKERS; SAMPLE;

D O I：

10.1007/s00394-016-1165-5

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide ( HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. Results The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. Conclusions Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in nonsmoking postmenopausal women from the EPIC cohort.

引用

页码：1157 / 1168

页数：12

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