Immune cell neural interactions and their contributions to sickle cell disease

被引：8

作者：

Sagi, Varun ^{[1
]}

Mittal, Aditya ^{[1
]}

Gupta, Mihir ^{[2
]}

Gupta, Kalpna ^{[1
]}

机构：

[1] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Vasc Biol Ctr, Box 736 UMHC, Minneapolis, MN 55455 USA

[2] Univ Calif San Diego, Dept Neurosurg, La Jolla, CA 92093 USA

来源：

NEUROSCIENCE LETTERS | 2019年 / 699卷

关键词：

Sickle cell disease; Pain; Mast cells; Serpins; Inflammation; MAST-CELLS; CYCLOOXYGENASE-2; EXPRESSION; SUBSTANCE-P; PAIN; ACTIVATION; MECHANISMS; SENSITIZATION; MICE; ADHESION; NEURONS;

D O I：

10.1016/j.neulet.2019.02.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Cellular and soluble mediators create an inflammatory and neuroinflammatory microenvironment contributing to neurogenic inflammation and acute and chronic pain. In this review we highlight relevant neuro-immune interactions that contribute to the pathobiology of SCD.

引用

页码：167 / 171

页数：5

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