Immune cell neural interactions and their contributions to sickle cell disease

被引：8

作者：

Sagi, Varun ^{[1
]}

Mittal, Aditya ^{[1
]}

Gupta, Mihir ^{[2
]}

Gupta, Kalpna ^{[1
]}

机构：

[1] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Vasc Biol Ctr, Box 736 UMHC, Minneapolis, MN 55455 USA

[2] Univ Calif San Diego, Dept Neurosurg, La Jolla, CA 92093 USA

来源：

NEUROSCIENCE LETTERS | 2019年 / 699卷

关键词：

Sickle cell disease; Pain; Mast cells; Serpins; Inflammation; MAST-CELLS; CYCLOOXYGENASE-2; EXPRESSION; SUBSTANCE-P; PAIN; ACTIVATION; MECHANISMS; SENSITIZATION; MICE; ADHESION; NEURONS;

D O I：

10.1016/j.neulet.2019.02.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Cellular and soluble mediators create an inflammatory and neuroinflammatory microenvironment contributing to neurogenic inflammation and acute and chronic pain. In this review we highlight relevant neuro-immune interactions that contribute to the pathobiology of SCD.

引用

页码：167 / 171

页数：5

共 72 条

[1] Regulation of Elastase By SerpinA3N Contributes to Pain in Sickle Cell Disease [J].

Aich, Anupam ;

Paul, Jinny ;

Lei, Jianxun ;

Wang, Ying ;

Bagchi, Anindya ;

Gupta, Kalpna .

BLOOD, 2016, 128 (22)

[2] Mast Cell-Mediated Mechanisms of Nociception [J].

Aich, Anupam ;

Afrin, Lawrence B. ;

Gupta, Kalpna .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (12) :29069-29092

[3]

Ballas S.K., 2015, Sickle cell pain

[4] Sickle cell pain: a critical reappraisal [J].

Ballas, Samir K. ;

Gupta, Kalpna ;

Adams-Graves, Patricia .

BLOOD, 2012, 120 (18) :3647-3656

[5] Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease [J].

Belcher, John D. ;

Chen, Chunsheng ;

Julia Nguyen ;

Milbauer, Liming ;

Abdulla, Fuad ;

Alayash, Abdu I. ;

Smith, Ann ;

Nath, Karl A. ;

Hebbel, Robert P. ;

Vercellotti, Gregory M. .

BLOOD, 2014, 123 (03) :377-390

[6] Substance P is increased in patients with sickle cell disease and associated with haemolysis and hydroxycarbamide use [J].

Brandow, Amanda M. ;

Wandersee, Nancy J. ;

Dasgupta, Mahua ;

Hoffmann, Raymond G. ;

Hillery, Cheryl A. ;

Stucky, Cheryl L. ;

Panepinto, Julie A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2016, 175 (02) :237-245

[7] Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature [J].

Brandow, Amanda M. ;

Farley, Rebecca A. ;

Panepinto, Julie A. .

PEDIATRIC BLOOD & CANCER, 2015, 62 (09) :1501-1511

[8] Patients with sickle cell disease have increased sensitivity to cold and heat [J].

Brandow, Amanda M. ;

Stucky, Cheryl L. ;

Hillery, Cheryl A. ;

Hoffmann, Raymond G. ;

Panepinto, Julie A. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (01) :37-43

[9] Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness [J].

Cain, David M. ;

Vang, Derek ;

Simone, Donald A. ;

Hebbel, Robert P. ;

Gupta, Kalpna .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 156 (04) :535-544

[10] An Evaluation of Central Sensitization in Patients With Sickle Cell Disease [J].

Campbell, Claudia M. ;

Moscou-Jackson, Gyasi ;

Carroll, C. Patrick ;

Kiley, Kasey ;

Haywood, Carlton, Jr. ;

Lanzkron, Sophie ;

Hand, Matthew ;

Edwards, Robert R. ;

Haythornthwaite, Jennifer A. .

JOURNAL OF PAIN, 2016, 17 (05) :617-627

← 1 2 3 4 5 6 7 8 →