Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

被引：52

作者：

Hannah, Jeffrey

Zhou, Pengbo ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA

来源：

DNA REPAIR | 2009年 / 8卷 / 04期

关键词：

Ubiquitin; Cullin-RING ligase; Nucleotide excision repair; NUCLEOTIDE EXCISION-REPAIR; SCF-BETA-TRCP; REPLICATION CHECKPOINT RESPONSE; DEPENDENT KINASE INHIBITOR; CELL NUCLEAR ANTIGEN; PIGMENTOSUM GROUP-E; RNA-POLYMERASE-II; UV-IRRADIATION; S-PHASE; COP9; SIGNALOSOME;

D O I：

10.1016/j.dnarep.2009.01.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell cycle and allow time for NER action. Recent studies uncovered critical roles for ubiquitin-mediated post-translational modifications in controlling both NER and checkpoint functions. In this review, we will discuss recent progress in delineating the roles of cullin-RING E3 ubiquitin ligases in orchestrating the cellular DNA damage response through ubiquitination of NER factors, histones, and checkpoint effectors. (C) 2009 Elsevier B.V. All rights reserved.

引用

收藏

页码：536 / 543

页数：8

相关论文

共 98 条

[1] PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex [J].

Abbas, Tarek ;

Sivaprasad, Uma ;

Terai, Kenta ;

Amador, Virginia ;

Pagano, Michele ;

Dutta, Anindya .

GENES & DEVELOPMENT, 2008, 22 (18) :2496-2506

[2] MAMMALIAN DNA NUCLEOTIDE EXCISION-REPAIR RECONSTITUTED WITH PURIFIED PROTEIN-COMPONENTS [J].

ABOUSSEKHRA, A ;

BIGGERSTAFF, M ;

SHIVJI, MKK ;

VILPO, JA ;

MONCOLLIN, V ;

PODUST, VN ;

PROTIC, M ;

HUBSCHER, U ;

EGLY, JM ;

WOOD, RD .

CELL, 1995, 80 (06) :859-868

[3] The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts [J].

Adimoolam, S ;

Lin, CX ;

Ford, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :25813-25822

[4] JAMM: A metalloprotease-like zinc site in the proteasome and signalosome [J].

Ambroggio, XI ;

Rees, DC ;

Deshaies, RJ .

PLOS BIOLOGY, 2004, 2 (01) :113-119

[5] Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery [J].

Angers, Stephane ;

Li, Ti ;

Yi, Xianhua ;

MacCoss, Michael J. ;

Moon, Randall T. ;

Zheng, Ning .

NATURE, 2006, 443 (7111) :590-593

[6]

[Anonymous], 2005, DNA REPAIR MUTAGENES

[7] PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication [J].

Arias, EE ;

Walter, JC .

NATURE CELL BIOLOGY, 2006, 8 (01) :84-U33

[8] p53 and p21 regulate error-prone DNA repair to yield a lower mutation load [J].

Avkin, Sharon ;

Sevilya, Ziv ;

Toube, Leanne ;

Geacintov, Nicholas ;

Chaney, Stephen G. ;

Oren, Moshe ;

Livneh, Zvi .

MOLECULAR CELL, 2006, 22 (03) :407-413

[9] SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box [J].

Bai, C ;

Sen, P ;

Hofmann, K ;

Ma, L ;

Goebl, M ;

Harper, JW ;

Elledge, SJ .

CELL, 1996, 86 (02) :263-274

[10] Mammalian G1- and S-phase checkpoints in response to DNA damage [J].

Bartek, J ;

Lukas, J .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (06) :738-747

← 1 2 3 4 5 6 7 8 9 10 →