Idiopathic eosinophilic pneumonia in children: the French experience

被引：17

作者：

Giovannini-Chami, Lisa ^{[1
,2
]}

Hadchouel, Alice ^{[3
,4
]}

Nathan, Nadia ^{[5
,6
]}

Bremont, Francois ^{[7
]}

Dubus, Jean-Christophe ^{[8
]}

Fayon, Michael ^{[9
]}

Houdouin, Veronique ^{[10
,11
]}

Berlioz-Baudoin, Michele ^{[1
]}

Feret, Virginie ^{[9
]}

Leblanc, Thierry ^{[12
]}

Morelle, Karine ^{[7
]}

Albertini, Marc ^{[1
,2
]}

Clement, Annick ^{[5
,6
]}

de Blic, Jacques ^{[3
,4
]}

机构：

[1] CHU Lenval, Hop Pediat Nice, Pediat Pulmonol & Allergy Dept, F-06200 Nice, France

[2] Univ Nice Sophia Antipolis, F-06000 Nice, France

[3] Hop Necker Enfants Malad, AP HP, Pediat Pulmonol & Allergy Dept, F-75015 Paris, France

[4] Univ Paris 05, F-75005 Paris, France

[5] Hop Trousseau, AP HP, Pediat Pulmonol Dept, F-75012 Paris, France

[6] Univ Paris 06, INSERM, UMR S U938, F-75012 Paris, France

[7] Ctr Hosp Univ Toulouse, Pediat Pulmonol Dept, Toulouse, France

[8] Ctr Hosp Univ Marseille, Pediat Pulmonol Dept, Marseille, France

[9] Ctr Hosp Univ Bordeaux, Pediat Pulmonol Dept, Dept Pediat, CIC 0005, F-33000 Bordeaux, France

[10] Hop Robert Debre, AP HP, Pediat Pulmonol Dept, F-75019 Paris, France

[11] Univ Paris Diderot VII, F-75 Paris, France

[12] Hop Robert Debre, AP HP, Pediat Hematol Dept, F-75019 Paris, France

来源：

ORPHANET JOURNAL OF RARE DISEASES | 2014年 / 9卷

关键词：

Idiopathic chronic eosinophilic pneumonia; Idiopathic acute eosinophilic pneumonia; Child; Eosinophilic lung disease; Interstitial lung disease; DESQUAMATIVE INTERSTITIAL PNEUMONIA; BRONCHOALVEOLAR LAVAGE FLUID; RESPIRATORY-FAILURE; LUNG-DISEASES; FOLLOW-UP; T-CELLS; ASTHMA; FIBROSIS; BOY;

D O I：

10.1186/1750-1172-9-28

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Idiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children. Methods: We retrospectively analyzed all cases of ICEP and IAEP in children that were retrieved from French Reference Centers for rare pediatric lung diseases. Results: Five cases of pediatric ICEP were identified. Corticosteroid or immunosuppressive therapy dramatically improved the outcome in three cases. The remaining two cases had a persistent interstitial pattern with progressive development of cystic airspace lesions. Three cases of IAEP in adolescents were reported, with one requiring four days of extracorporeal membrane oxygenation. Conclusion: ICEP is a rare disease with a polymorphic clinical presentation in children. We identified patients with persistent interstitial patterns progressing to cystic airspace regions, for which the boundaries with idiopathic interstitial pneumonias are difficult to establish. We therefore propose a specific pediatric definition and classification algorithm. IAEP in children remains an inflammatory reaction of the lung to an acute toxic exposure, mainly tobacco, as in adults. International studies are required to comprehensively assess the various clinical forms of the disease as well as the appropriate therapeutic regimens.

引用

页数：11

共 38 条

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