Cancer pagurus is much appreciated in Southern Europe, where the muscle, hepatopancreas, and gonads are consumed regularly with peaks in summer and December. The elemental contents of C. pagurus edible tissues were analyzed in this study during the four seasons. Results indicate that the content varied with tissue, season, and sex. The hepatopancreas had more S, Cl, Ca, Br, Sr, Fe, Cu, Cd, and Pb, the gonads had a higher concentration of Na, and the muscle was richer in Zn. Autumn and winter corresponded to a high Mg, S, Cl, K, Ca, Fe, and Zn content in both the muscle and hepatopancreas. Female gonads had more Fe, Zn, As, and Se than males but less Ca, Cl, Br, and Sr. Regarding toxic elements for human consumption, the levels of As, Hg, and Pb found in all edible tissues pose minimal risks to consumers. However, Cd concentration in the hepatopancreas was always above the action limit. Therefore, we recommend moderate hepatopancreas consumption.