A comparative study on the effectiveness of losartan/hydrochlorothiazide and telmisartan/hydrochlorothiazide in patients with hypertension

被引：7

作者：

Hamada, Toshihiro ^{[1
]}

Kuwabara, Masanari ^{[2
]}

Watanabe, Arisa ^{[1
]}

Mizuta, Einosuke ^{[3
]}

Ohtahara, Akira ^{[3
]}

Omodani, Hiroki ^{[4
]}

Watanabe, Masashi ^{[5
]}

Nakamura, Hiroki ^{[6
]}

Hirota, Yutaka ^{[7
]}

Miyazaki, Satoshi ^{[8
]}

Kato, Masahiko ^{[9
]}

Ogino, Kazuhide ^{[10
]}

Kosaka, Hiroki ^{[11
]}

Haruaki, Ninomiya ^{[12
]}

Taniguchi, Shin-ichi ^{[1
]}

Yamamoto, Kazuhiro ^{[9
]}

Kotake, Hiroshi ^{[13
]}

Hisatome, Ichiro ^{[2
]}

机构：

[1] Tottori Univ, Fac Med, Dept Reg Med, Yonago, Tottori 6838503, Japan

[2] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut, Yonago, Tottori 6838503, Japan

[3] Sanin Rosai Hosp, Dept Cardiovasc Med, Yonago, Tottori, Japan

[4] Omodani Clin, Div Cardiovasc Med, Yonago, Tottori, Japan

[5] Watanabe Clin, Div Cardiovasc Med, Sakaiminato, Japan

[6] Nakamura Clin, Tottori, Japan

[7] Tomimasu Surg & Primary Care Clin, Yonago, Tottori, Japan

[8] Nojima Hosp, Div Cardiol, Kurayoshi, Japan

[9] Tottori Univ, Fac Med, Div Mol Med & Therapeut, Yonago, Tottori 6838503, Japan

[10] Tottori Univ Hosp, Ctr Clin Residency Program, Yonago, Tottori, Japan

[11] Tottori Red Cross Hosp, Div Internal Med, Tottori, Japan

[12] Tottori Univ, Fac Med, Dept Biochem Regulat, Yonago, Tottori 6838503, Japan

[13] Kotake Clin, Div Cardiovasc Med, Yonago, Tottori, Japan

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2014年 / 36卷 / 04期

关键词：

HOMA-R; hydrochlorothiazide; losartan; serum uric acid; telmisartan; URIC-ACID; URATE LEVELS; BENZBROMARONE; COMBINATION; LOSARTAN; THERAPY;

D O I：

10.3109/10641963.2013.810228

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: Long-term effects of a low-dose hydrochlorothiazide (HCTZ) with losartan (LOS) on uric acid (UA) metabolism as well as glucose metabolism have been studied in hypertensive patients in comparison with those of a low-dose HCTZ with telmisartan (TEL). Method: Fifty-nine hypertensive patients were allocated to a combination therapy with either losartan (50 mg/day)/HCTZ (12.5 mg/day) (LOS + HCTZ group: n = 37) or telmisartan (40 mg/day)/HCTZ (12.5 mg/day) (TEL + HCTZ group: n = 22), respectively. Before and 1 year after the treatment, blood pressure and biochemical parameters of blood and urine were evaluated. Results: Both systolic and diastolic blood pressures significantly decreased in two groups, without any statistical differences among them. LOS + HCTZ caused no changes in the serum UA level or the ratio of UA clearance to creatinine clearance (CUA/Ccr), whereas TEL + HCTZ significantly increased the serum UA level and reduced CUA/Ccr. LOS + HCTZ did not influence CUA/Ccr in patients with their serum UA below 5.4 mg/dl, while LOS + HCTZ significantly increased CUA/Ccr in patients with their serum UA above 5.5 mg/dl. TEL + HCTZ significantly reduced CUA/Ccr in patients with their serum UA below and above 5.4 mg/dl to increase serum UA level significantly. Neither combination therapies caused any changes in fasting plasma glucose, HbA1c and HOMA-R. In patients with their serum UA level above 5.4 mg/dl, TEL + HCTZ increased HOMA-R, whereas LOS + HCTZ did not. Conclusions: LOS + HCTZ did not influence UA metabolism as well as glucose metabolism, likely because of inhibitory action of losartan on URAT1, although TEL + HCTZ were accompanied with impairment of the UA metabolism and glucose metabolism.

引用

页码：251 / 257

页数：7

共 16 条

[1] Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study [J].

Choi, Hyon K. ;

Soriano, Lucia Cea ;

Zhang, Yuqing ;

Garcia Rodriguez, Luis A. .

BRITISH MEDICAL JOURNAL, 2012, 344

[2] Molecular identification of a renal urate-anion exchanger that regulates blood urate levels [J].

Enomoto, A ;

Kimura, H ;

Chairoungdua, A ;

Shigeta, Y ;

Jutabha, P ;

Cha, SH ;

Hosoyamada, M ;

Takeda, M ;

Sekine, T ;

Igarashi, T ;

Matsuo, H ;

Kikuchi, Y ;

Oda, T ;

Ichida, K ;

Hosoya, T ;

Shimokata, K ;

Niwa, T ;

Kanai, Y ;

Endou, H .

NATURE, 2002, 417 (6887) :447-452

[3] Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT1) in hypertensive patients [J].

Hamada, Toshihiro ;

Ichica, Kimiyoshi ;

Hosoyamada, Makoto ;

Mizuta, Einosuke ;

Yanagihara, Kiyotaka ;

Sonoyama, Kazuhiko ;

Sugihara, Shinobu ;

Igawa, Osamu ;

Hosoya, Tatsuo ;

Ohtahara, Akira ;

Shigamasa, Chiaki ;

Yamamoto, Yasutaka ;

Ninomiya, Haruaki ;

Hisatome, Ichiro .

AMERICAN JOURNAL OF HYPERTENSION, 2008, 21 (10) :1157-1162

[4]

Hamada T, 2010, ARZNEIMITTEL-FORSCH, V60, P71, DOI 10.1055/s-0031-1296251

[5] Effects of Combined Antihypertensive Therapy with Losartan/Hydrochlorothiazide on Uric Acid Metabolism [J].

Hosoya, Tatsuo ;

Kuriyama, Satoru ;

Yoshizawa, Takeo ;

Kobayashi, Akimitsu ;

Otsuka, Yasushi ;

Ohno, Iwao .

INTERNAL MEDICINE, 2012, 51 (18) :2509-2514

[6] Effects of Benzbromarone and Allopurinol on Adiponectin In Vivo and In Vitro [J].

Inokuchi, T. ;

Tsutsumi, Z. ;

Takahashi, S. ;

Ka, T. ;

Yamamoto, A. ;

Moriwaki, Y. ;

Masuzaki, H. ;

Yamamoto, T. .

HORMONE AND METABOLIC RESEARCH, 2009, 41 (04) :327-332

[7] Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter [J].

Iwanaga, Takashi ;

Sato, Masanobu ;

Maeda, Tomoji ;

Ogihara, Toshio ;

Tamai, Ikumi .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 320 (01) :211-217

[8] One-year effectiveness and safety of open-label losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitors [J].

Kita, Toshihiro ;

Yokota, Naoto ;

Ichiki, Yoshinari ;

Ayabe, Takao ;

Etoh, Takuma ;

Tamaki, Noboru ;

Kato, Johji ;

Eto, Tanenao ;

Kitamura, Kazuo .

HYPERTENSION RESEARCH, 2010, 33 (04) :320-325

[9] Comparison of Therapies Between Fixed-Dose Telmisartan/Hydrochlorothiazide and Losartan/Hydrochlorothiazide in Patients With Mild to Moderate Hypertension [J].

Minami, Junichi ;

Furukata, Satoshi ;

Ishimitsu, Toshihiko ;

Matsuoka, Hiroaki .

INTERNATIONAL HEART JOURNAL, 2009, 50 (01) :85-93

[10]

Ogihara T, 2009, HYPERTENS RES, V32, P3, DOI 10.1038/hr.2008.15

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