Selective N-alkylation of primary amines with R-NH2 • HBr and alkyl bromides using a competitive deprotonation/protonation strategy

被引：44

作者：

Bhattacharyya, Shubhankar ^{[1
]}

Pathak, Uma ^{[1
]}

Mathur, Sweta ^{[1
]}

Vishnoi, Subodh ^{[1
]}

Jain, Rajeev ^{[2
]}

机构：

[1] Def R&D Estab, Synthet Chem Div, Gwalior 474002, India

[2] Jiwaji Univ, Sch Studies Chem, Gwalior 474002, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 35期

关键词：

DISCOVERY; ALCOHOLS;

D O I：

10.1039/c4ra01915f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monoalkylation of primary amines using amine hydrobromides and alkyl bromides has been carried out. Under controlled reaction conditions the reactant primary amine was selectively deprotonated and made available for reaction, while the newly generated secondary amine remained protonated, and did not participate in alkylation further. Reaction was carried out under mild reaction conditions and was applicable to a wide range of primary amines and alkyl bromides.

引用

页码：18229 / 18233

页数：5

共 30 条

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