Mechanism of action of hemolysin III from Bacillus cereus

被引：90
作者：
Baida, GE
Kuzmin, NP
机构：
[1] Inst. of Biochem. and Physiol. of M., Russian Academy of Sciences, Pushchino, Moscow Region
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1996年 / 1284卷 / 02期
关键词：
hemolysin III; pore formation; (Bacillus cereus);
D O I：
10.1016/S0005-2736(96)00168-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacillus cereus hemolysin III activity was tested in crude extracts from Escherichia coli carrying the hly-III gene. It was concluded that hemolysin III is a pore-forming hemolysin with a functional pore diameter of about 3-3.5 nm. Hemolysis occurs in at least three steps: (i) the temperature-dependent binding of the HIV-III monomers to the erythrocyte membrane: (ii) the temperature-dependent formation of the transmembrane oligomeric pore; (iii) the temperature-independent erythrocyte lysis.
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收藏
页码：122 / 124
页数：3
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