New Strategies in Ewing Sarcoma: Lost in Translation?

被引：22

作者：

Arnaldez, Fernanda I. ^{[1
]}

Helman, Lee J. ^{[1
]}

机构：

[1] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 12期

关键词：

CHILDRENS-ONCOLOGY-GROUP; FACTOR-I RECEPTOR; PEDIATRIC SOLID TUMORS; GENE-EXPRESSION; HISTONE DEACETYLASE; TARGET GENE; PHASE-II; TRANSCRIPTIONAL REPRESSION; MONOCLONAL-ANTIBODY; INHIBITS GROWTH;

D O I：

10.1158/1078-0432.CCR-13-0633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ewing sarcoma is the second most common pediatric malignant bone tumor. Aggressive multimodality therapy has led to an improvement in outcomes, particularly in patients with localized disease. However, therapy-related toxicities are not trivial, and the prognosis for patients with relapsed and/or metastatic disease continues to be poor. In this article, we outline some of the promising therapies that have the potential to change the Ewing sarcoma therapeutic paradigm in the not-too-distant future: insulin-like growth factor receptor inhibitors, targeting of the fusion protein, epigenetic manipulation, PARP inhibitors, and immunotherapy. (C) 2014 AACR.

引用

页码：3050 / 3056

页数：7

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