New Strategies in Ewing Sarcoma: Lost in Translation?

被引：22
作者：
Arnaldez, Fernanda I. [1 ]
Helman, Lee J. [1 ]
机构：
[1] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA
来源：
CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 12期
关键词：
CHILDRENS-ONCOLOGY-GROUP; FACTOR-I RECEPTOR; PEDIATRIC SOLID TUMORS; GENE-EXPRESSION; HISTONE DEACETYLASE; TARGET GENE; PHASE-II; TRANSCRIPTIONAL REPRESSION; MONOCLONAL-ANTIBODY; INHIBITS GROWTH;
D O I：
10.1158/1078-0432.CCR-13-0633
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ewing sarcoma is the second most common pediatric malignant bone tumor. Aggressive multimodality therapy has led to an improvement in outcomes, particularly in patients with localized disease. However, therapy-related toxicities are not trivial, and the prognosis for patients with relapsed and/or metastatic disease continues to be poor. In this article, we outline some of the promising therapies that have the potential to change the Ewing sarcoma therapeutic paradigm in the not-too-distant future: insulin-like growth factor receptor inhibitors, targeting of the fusion protein, epigenetic manipulation, PARP inhibitors, and immunotherapy. (C) 2014 AACR.
引用
收藏
页码：3050 / 3056
页数：7
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