Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

被引：30

作者：

Witlox, Lenja ^{[1
]}

Schagen, Sanne B. ^{[2
]}

de Ruiter, Michiel B. ^{[2
]}

Geerlings, Mirjam, I ^{[1
]}

Peeters, Petra H. M. ^{[1
]}

Koevoets, Emmie W. ^{[1
,2
]}

van der Wall, Elsken ^{[3
]}

Stuiver, Martijn ^{[4
,5
]}

Sonke, Gabe ^{[4
]}

Velthuis, Miranda J. ^{[6
]}

van der Palen, Job A. M. ^{[7
,8
]}

Jobsen, Jan J. ^{[7
]}

May, Anne M. ^{[1
]}

Monninkhof, E. M. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[2] Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[3] Univ Med Ctr Utrecht, Dept Med Oncol, Utrecht, Netherlands

[4] Netherlands Canc Inst, Ctr Qual Life, Amsterdam, Netherlands

[5] Univ Appl Sci, Fac Hlth, ACHIEVE Ctr Appl Res, Amsterdam, Netherlands

[6] Netherlands Comprehens Canc Org IKNL, Utrecht, Netherlands

[7] Med Spectrum Twente, Med Sch Twente, Enschede, Netherlands

[8] Univ Twente, Dept Res Methodol, Measurement, Enschede, Netherlands

来源：

BMJ OPEN | 2019年 / 9卷 / 06期

关键词：

QUALITY-OF-LIFE; AEROBIC EXERCISE; INFLAMMATORY MARKERS; INCIDENTAL FINDINGS; WORK ABILITY; SURVIVORS; WOMEN; PERFORMANCE; IMPAIRMENT; MANAGEMENT;

D O I：

10.1136/bmjopen-2018-028117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction After treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive effects in healthy older adults and people with mild cognitive impairment. The Physical Activity and Memory study aims to investigate the effect of physical exercise on cognitive functioning and brain measures in chemotherapy-exposed patients with breast cancer with cognitive problems. Methods and analytics One hundred and eighty patients with breast cancer with cognitive problems 2-4 years after diagnosis are randomised (1:1) into an exercise intervention or a control group. The 6-month exercise intervention consists of twice a week 1-hour aerobic and strength exercises supervised by a physiotherapist and twice a week 1-hour Nordic or power walking. The control group is asked to maintain their habitual activity pattern during 6months. The primary outcome (verbal learning) is measured at baseline and 6 months. Further measurements include online neuropsychological tests, self-reported cognitive complaints, a 3-tesla brain MRI, patient-reported outcomes (quality of life, fatigue, depression, anxiety, work performance), blood sampling and physical fitness. The MRI scans and blood sampling will he used to gain insight into underlying mechanisms. At 18 months online neuropsychological tests, self-reported cognitive complaints and patient-reported outcomes will be repeated. Ethics and dissemination Study results may impact usual care if physical exercise improves cognitive functioning for breast cancer survivors.

引用

页数：9

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