MiR-215 modulates gastric cancer cell proliferation by targeting RB1

被引：90
作者：
Deng, Yujie [1 ,2 ]
Huang, Zhenxia [3 ,4 ]
Xu, Yanjun [1 ,2 ]
Jin, Juan [1 ,2 ]
Zhuo, Wei [1 ,2 ,4 ]
Zhang, Cheng [1 ,2 ]
Zhang, Xuting [1 ,2 ]
Shen, Minhong [1 ,2 ]
Yan, Xiaoyi [1 ,2 ]
Wang, Liangjing [3 ]
Wang, Xiaojia [5 ]
Kang, Yibin [6 ]
Si, Jianmin [3 ,4 ]
Zhou, Tianhua [1 ,2 ,4 ]
机构：
[1] Zhejiang Univ, Sch Med, Ctr Dis Modeling, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Program Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Clin Res Inst,Gastroenterol Lab, Hangzhou 310016, Zhejiang, Peoples R China
[4] Zhejiang Univ, Inst Gastroenterol, Hangzhou 310016, Zhejiang, Peoples R China
[5] Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
[6] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源：
CANCER LETTERS | 2014年 / 342卷 / 01期
关键词：
Gastric cancer; MiR-215; Retinoblastoma; Proliferation; DOWN-REGULATION; P53-INDUCIBLE MICRORNAS; MOLECULAR-BIOLOGY; CYCLE ARREST; PROTEIN; RETINOBLASTOMA; EXPRESSION; GENE; CARCINOMA; DIFFERENTIATION;
D O I：
10.1016/j.canlet.2013.08.033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：27 / 35
页数：9
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