MiR-215 modulates gastric cancer cell proliferation by targeting RB1

被引：90

作者：

Deng, Yujie ^{[1
,2
]}

Huang, Zhenxia ^{[3
,4
]}

Xu, Yanjun ^{[1
,2
]}

Jin, Juan ^{[1
,2
]}

Zhuo, Wei ^{[1
,2
,4
]}

Zhang, Cheng ^{[1
,2
]}

Zhang, Xuting ^{[1
,2
]}

Shen, Minhong ^{[1
,2
]}

Yan, Xiaoyi ^{[1
,2
]}

Wang, Liangjing ^{[3
]}

Wang, Xiaojia ^{[5
]}

Kang, Yibin ^{[6
]}

Si, Jianmin ^{[3
,4
]}

Zhou, Tianhua ^{[1
,2
,4
]}

机构：

[1] Zhejiang Univ, Sch Med, Ctr Dis Modeling, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Program Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Clin Res Inst,Gastroenterol Lab, Hangzhou 310016, Zhejiang, Peoples R China

[4] Zhejiang Univ, Inst Gastroenterol, Hangzhou 310016, Zhejiang, Peoples R China

[5] Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

[6] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CANCER LETTERS | 2014年 / 342卷 / 01期

关键词：

Gastric cancer; MiR-215; Retinoblastoma; Proliferation; DOWN-REGULATION; P53-INDUCIBLE MICRORNAS; MOLECULAR-BIOLOGY; CYCLE ARREST; PROTEIN; RETINOBLASTOMA; EXPRESSION; GENE; CARCINOMA; DIFFERENTIATION;

D O I：

10.1016/j.canlet.2013.08.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 35

页数：9

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